基于网络药理学探讨黄连阿胶汤治疗失眠症的作用机制

目的采用网络药理学方法寻找黄连阿胶汤的有效成分、治疗靶标。方法根据药代动力学参数筛选药物成分,通过网络药理学方法挖掘药物和疾病靶标并构建药物-靶点网络,研究黄连阿胶汤成分的作用机制。结果发现黄连阿胶汤中的氢化小檗碱、β-谷甾醇、山姜素、山柰酚、小檗浸碱、荠苎黄酮等19个成分可能通过调控5-羟色胺、多巴胺、γ氨基丁酸、阿片受体、乙酰胆碱等25个靶点作用于失眠症治疗。结论黄连阿胶汤可能主要通过多个靶点调控多种神经递质发挥对失眠症的治疗作用。

The mechanism of Huanglian-Ejiao Decoction in the treatment of insomnia based on network pharmacology

Objective By taking network pharmacology approach to search for active components and the rapeutic targets of Huanglian-Ejiao Decoction.Methods According to the pharmacokinetic parameters,this research screened components of this decoction,and diged the drugs and disease targets with network pharmacology and constructed the drug-target-pathway network by Cytoscape system to investigate the mechanism of Huanglian-Ejiao Decoction.Results It was found that 19 components such as hydroberberine,β-sitosterol,curcumin,kaempferol,berberine and Ramie flavonoids in Huanglian-Ejiao Decoction could take effecton insomnia by regulating 25 targets such as 5-hydroxytryptamine,dopamine,gamma aminobutyric acid,opioid receptor and acetylcholine.Conclusion Huanglian-Ejiao Decoction may play an important role in treating insomnia by regulating multiple-targets.