西黄丸联合同步放化疗治疗局部宫颈癌的临床研究

目的:观察西黄丸联合同步放化疗治疗局部晚期宫颈癌的近期疗效,严重不良反应和对患者生活质量及免疫状态的影响。方法:选择已发生无法手术切除的局部晚期宫颈癌患者62例,随机分为2组,对照组予同步放化疗,观察组予西黄丸联合同步放化疗,比较2组近期疗效、严重不良反应、生活质量,并比较2组患者细胞免疫状态的差异。结果:观察组与对照组近期有效率比较无统计学意义(P0.05);观察组在延缓肿瘤进展时间、减少(血液、放射性损伤及疲劳等)不良反应、提高生活质量及抗肿瘤细胞免疫状态等方面优于对照组(P均0.05)。结论:西黄丸联合同步放化疗可改善局部晚期宫颈癌患者的生活质量,降低常见的严重不良反应,并能在一定程度上激活抗肿瘤细胞免疫反应。

Effect of Xihuang Pills Combined with Concurrent Chemoradiotherapy on Locally Advanced Cervical Cancer

To observe the effect of Xihuang pills combined with concurrent chemoradiotherapy on locally advanced cervical cancer.Methods:Sixty-two patients with locally advanced cervical cancer were randomly divided into two groups: patients in control group were treated with concurrent chemoradiotherapy, and patients in observation group were treated with Xihuang pills combined with concurrent chemoradiotherapy. Indexes as the objective response rate (RR), toxicities, quality of life (QOL), and cellular immune status were compared.Results:There was no significant difference in RR between the two groups (P>0.05). Observation group was superior to control group in the aspects of TTP, toxicity, QOL and anti-tumor immune(P<0.05).Conclusion:Xihuang pills combined with concurrent chemoradiotherapy has advantages in improving QOL, reducing side effects, and activating anti-tumor immune response in patients with locally advanced cervical cancer.