| STUDY OF MORPHOLOGICAL CHANGES OF HEART IN VIRAL MYOCARDITIS CAUSED BY REPETITIVE INFECTION OF CVB3m |
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| 作者姓名： | 郭玲 周令望 孙辉 钟学宽 |
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| 作者单位： | Keshan Disease Institute, Harbin Medical University, Harbin 150086, China |
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| 摘 要： | Objective To investigate the morphological changes of heart in viral myocarditis caused by repetitive infection of CVB3m. Methods 4-week-old mice were infected four times intraperitoneally with a timedependent dose and killed at the 10th, 30th and 60th day after the final infection respectively, then we examined the heart changes and collagen hyperplasia by HE, VG stain and 1HC. Results Heart damage appeared very serious at the tenth day, even there were small necrotic foci at the day of 30th, but we could not see any injury of heart 2 months later after final infection. Collagen turned up at the tenth day and there was much more collagen in heart and increased PCVA, CVF index at the sixtieth day. The 1HC of collagen demonstrated the collagen I hyperplasia was much obvious compared to collagen Ⅲ. Conclusion It strongly indicated that repetitive infection of CVB3m could lead to heart fibrosis and ventricular remodeling, which resulted in decreased systolic and diastolic function of heart.
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| 关 键 词： | 形态学 心肌炎 心脏损伤 治疗 临床表现 |
| 收稿时间： | 2005-04-11 |
STUDY OF MORPHOLOGICAL CHANGES OF HEART IN VIRAL MYOCARDITIS CAUSED BY REPETITIVE INFECTION OF CVB3m |
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| GUO Ling,ZHOU Ling-wang,SUN Hui,ZHONG Xue-kuan.STUDY OF MORPHOLOGICAL CHANGES OF HEART IN VIRAL MYOCARDITIS CAUSED BY REPETITIVE INFECTION OF CVB3m[J].Journal of Shanghai Second Medical University(Foreign Language Edition),2006,18(1):67-70. |
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| Authors: | GUO Ling ZHOU Ling-wang SUN Hui ZHONG Xue-kuan |
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| Abstract: | Objective To investigate the morphological changes of heart in viral myocarditis caused by repetitive infection of CVB3m. Methods 4-week-old mice were infected four times intraperitoneally with a time-dependent dose and killed at the 10th,30th and 60th day after the final infection respectively, then we examined the heart changes and collagen hyperplasia by HE, VG stain and IHC. Results Heart damage appeared very serious at the tenth day, even there were small necrotic foci at the day of 30th, but we could not see any injury of heart 2 months later after final infection. Collagen turned up at the tenth day and there was much more collagen in heart and increased PCVA, CVF index at the sixtieth day. The IHC of collagen demonstrated the collagen I hyperplasia was much obvious compared to collagen III. Conclusion It strongly indicated that repetitive infection of CVB3m could lead to heart fibrosis and ventricular remodeling, which resulted in decreased systolic and diastolic function of heart. |
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| Keywords: | repetitive infection ventricular remodeling heart injury |
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