| 腮腺多形性腺瘤及恶性多形性腺瘤c－erbB－2癌基因扩增与患者预后的关系 |
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| 引用本文： | 阎颖,郭庆科,南平,唐文杰,肖光裕,张盈华,郝新保,张健,徐平.腮腺多形性腺瘤及恶性多形性腺瘤c－erbB－2癌基因扩增与患者预后的关系[J].第四军医大学学报,1994(1). |
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| 作者姓名： | 阎颖 郭庆科 南平 唐文杰 肖光裕 张盈华 郝新保 张健 徐平 |
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| 作者单位： | 唐都医院口腔科 |
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| 摘 要： | 作者采用ＤＮＡ斑点杂交方法，对３５例腮腺多形性腺瘤（ＰＡ）和３６例恶性多形性腺瘤（ＭＰＡ）石蜡包埋组织中ｃ－ｅｒｂＢ－２癌基因扩增情况进行研究．结果表明，３５例ＰＡ中，６例扩增（１７．１４％）；３６例ＭＰＡ中，２２例扩增（６１．１１％）；两组扩增有显著差别（Ｐ＜０．０１）．扩增组ＰＡ恶变率（８３．３３％）明显高于无扩增组（３．４５％，Ｐ＜０．０１）．各临床分期的ＭＰＡｃ－ｅｒｂＢ－２扩增率无显著差异（Ｐ＞０．０５），而不同分化程度的ＭＰＡｃ－ｒｅｒｂＢ－２扩增率有显著差异（Ｐ＜０．０５）．扩增组ＭＰＡ术后复发率明显高于无扩增组（Ｐ＜０．０１）；ＭＰＡ术后五年生存率无扩增组高于扩增组（Ｐ＜０．０１）．提示：ｃ－ｅｒｂＢ－２癌基因扩增可能成为ＰＡ及ＭＰＡ有价值的预后指标．
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| 关 键 词： | 腮腺肿瘤，多形性腺瘤，癌基因，斑点杂交，预后 |
Study of the relation between c-erbB-2 Protooncogene amplificationand prognosis in parotid pleomorphic adenoma and parotid malignantpleomorphic adenoma |
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| YAN Ying,GUO Qing-Ke,NAN Ping ,TANG Wen-Jie,XIAO Guang-Yu,ZHANGYing-Hua,HAO Xin-Bao,ZHANG Jianl and XU Ping.Study of the relation between c-erbB-2 Protooncogene amplificationand prognosis in parotid pleomorphic adenoma and parotid malignantpleomorphic adenoma[J].Journal of the Fourth Military Medical University,1994(1). |
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| Authors: | YAN Ying GUO Qing-Ke NAN Ping TANG Wen-Jie XIAO Guang-Yu ZHANGYing-Hua HAO Xin-Bao ZHANG Jianl and XU Ping |
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| Institution: | YAN Ying1,GUO Qing-Ke1,NAN Ping 1,TANG Wen-Jie1,XIAO Guang-Yu1,ZHANGYing-Hua2,HAO Xin-Bao2,ZHANG Jianl and XU Ping11 Department of Stomatology,2Central Laboratory,Tangdu Hospital |
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| Abstract: | |
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| Keywords: | salivary neoplasms pleomorphic adenoma oncogene dot hybridization prognosis |
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