| 川芎嗪对咪达唑仑所致记忆障碍小鼠学习功能的影响 |
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| 引用本文： | 蒋月明,郭根花,王树桂,万晶,姚毅,周兴,宋潇,彭飞飞,刘金东,马涛,袁力勇.川芎嗪对咪达唑仑所致记忆障碍小鼠学习功能的影响[J].中华中医药学刊,2011(8):1823-1825. |
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| 作者姓名： | 蒋月明 郭根花 王树桂 万晶 姚毅 周兴 宋潇 彭飞飞 刘金东 马涛 袁力勇 |
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| 作者单位： | 徐州医学院麻醉学院;徐州医学院附属医院麻醉科;徐州医学院麻醉药理学教研室;宁波市妇女儿童医院麻醉科; |
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| 基金项目： | 江苏省高等学校大学生实践创新训练计划项目(2010798); 宁波市医学科技计划项目(2007014) |
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| 摘 要： | 目的:观察川芎嗪注射液(tetramethylpyrazine,T)对咪达唑仑(midazolam,M)所致记忆障碍小鼠学习功能的影响。方法:将小鼠分为4组:生理盐水组(NS组),咪达唑仑组(M组),川芎嗪50 mg.kg-1+咪达唑仑组(T50+M组),川芎嗪100 mg.kg-1+咪达唑仑组(T100+M组)。用避暗实验(step-through test)观察各组24h、48h的潜伏期(latency)和错误次数(error times)。结果:24h,与NS组相比,M组、T50+M组、T100+M组潜伏期明显缩短(P<0.01),错误次数增加(P<0.01或P<0.05);与M组或T50+M组相比,T100+M组错误次数明显增加(P<0.01);48h,与NS组相比,M组潜伏期缩短(P<0.05),错误次数明显增多(P<0.01),T50+M组或T100+M组两项指标均无统计学差异(P>0.05);与M组相比,T50+M组错误次数减少(P<0.05)。结论:大剂量川芎嗪能增强咪达唑仑的遗忘作用,24h后却表现出记忆保护的趋势。
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| 关 键 词： | 川芎嗪 咪达唑仑 避暗实验 学习记忆 遗忘 |
The effects of tetramethylpyrazine on midazolam-induced dysmnesia in mice |
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| JIANG Yue-ming,GUO Gen-hua,WANG Shu-gui,WAN Jing,YAO Yi,ZHOU Xing,SONG Xiao,PENG Fei-fei,LIU Jin-dong ,MA Tao,YUAN Li-yong.The effects of tetramethylpyrazine on midazolam-induced dysmnesia in mice[J].Chinese Archives of Traditional Chinese Medicine,2011(8):1823-1825. |
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| Authors: | JIANG Yue-ming GUO Gen-hua WANG Shu-gui WAN Jing YAO Yi ZHOU Xing SONG Xiao PENG Fei-fei LIU Jin-dong MA Tao YUAN Li-yong |
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| Institution: | JIANG Yue-ming1,GUO Gen-hua1,WANG Shu-gui1,WAN Jing1,YAO Yi1,ZHOU Xing1,SONG Xiao1,PENG Fei-fei1,LIU Jin-dong 2,MA Tao3,YUAN Li-yong4(1.School of Anesthesia,Xuzhou Medical College,Xuzhou 221002,Jiangsu,China,2.Department Anesthesiology of Affiliated Hospital of Xuzhou Medical College,3.Department of Anesthetic Pharmacology,4.Anesthesiology department of Ningbo Women and Children Hospital,Ningbo 315012,Zhejiang,China) |
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| Abstract: | Objective:To investigate the effects of tetramethylpyrazine on midazolam-induced dysmnesia in mice.Methods:The mice were divided into 4 groups(n=10): normal saline group(NS group),midazolam group(M group),tetramethylpyrazine 50mg kg-1+ midazolam group(T50+M group) and tetramethylpyrazine 100mg kg-1+ midazolam group(T100+M group).The latency and error times of each group were observed by the step-through test.Resuts: Compared with NS group at 24h,the lateny of M group,T50+M group and T100+M group decreased s... |
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| Keywords: | tetramethylpyrazine midazolam step-through test learning and memory dysmnesia |
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