调强适形放疗对鼻咽癌患者血清TGF-β1、IL-8和T淋巴细胞亚群水平的影响

目的 探讨调强适形放疗(IMRT)对鼻咽癌患者血清TGF-β1、IL-8和T淋巴细胞亚群水平的影响。 方法 将115例鼻咽癌患者按照放疗方式分为对照组(57例)与观察组(58例),分别采用常规二维放疗与IMRT治疗。比较2组患者5年生存率及复发情况、不良反应发生情况、治疗前后血清TGF-β1、IL-8与T淋巴细胞亚群水平的变化情况。 结果 ①观察组患者无区域复发生存率、无瘤生存率均显著高于对照组(P＜0.05),观察组患者局部复发率显著低于对照组(P＜0.05),观察组患者无远处转移生存率略大于对照组(P＞0.05)；②对照组患者放疗过程中不良反应总发生率为40.35%(23/57),观察组为34.48%(20/58),2组不良反应发生率差异无统计学意义(P＞0.05)；③2组患者治疗后血清TGF-β1及IL-8水平较治疗前均显著下降(P＜0.05),且观察组上述指标水平下降幅度均显著大于对照组(P＜0.05)；④2组患者治疗后CD3、CD4及CD4/CD8水平较治疗前均显著升高(P＜0.05),治疗后CD8水平较治疗前均显著下降(P＜0.05)。 结论 IMRT对鼻咽癌的疗效显著,可能是通过改善患者血清TGF-β1、IL-8及T淋巴细胞亚群水平来实现的。 

Effect of intensity modulated radiation therapy(IMRT) on the serum levels of TGF-1,IL-8 and T-lymphocyte subsets in patients with nasopharyngeal carcinoma

Objective To investigate the effects of intensity modulated radiation therapy(IMRT) on the serum levels of TGF-1,IL-8,and T-lymphocyte subsets in patients with nasopharyngeal carcinoma. Methods One hundred and fifteen patients with nasopharyngeal carcinoma were divided into the control group(n=57) and the observation group (n=58) according to the radiation therapy,and the patients were treated with conventional two-dimensional radiotherapy and IMRT.Comparison of two groups of patients with 5 year survival rate and recurrence,adverse reactions,the serum levels of TGF-β1,IL-8,and T lymphocyte subsets were compared before and after treatment. Results ①patients in the observation group showed no regional recurrence survival rate and disease-free survival rate were significantly higher than those in control group(P<0.05),the observation group of patients with local recurrence rate was significantly lower than the control group(P<0.05),observation group of patients with distant metastasis free survival rate was slightly higher than that of control group(P>0.05);②adverse reactions in the control group in the process of radiotherapy in patients with the total incidence rate was 40.35%(23/57),the observation group was 34.48%(20/58),there was no significant difference in the adverse reactions between the two groups(P>0.05);③the serum TGF-beta 1,and IL-8 levels in the two groups of patients after treatment were significantly lower than those before treatment(P<0.05-0.01),and in the observation group,the index level decreased significantly than the control group(P<0.05);④the CD3,CD4 and CD4/CD8 levels in the two groups of patients after treatment were significantly higher than before treatment (P<0.05),CD8 levels after and before treatment were both significantly decreased(P<0.05). Conclusion The effect of IMRT on nasopharyngeal carcinoma is significant,which may be achieved by improving the level of serum TGF-β1,IL-8,and T lymphocyte subsets in patients with nasopharyngeal carcinoma.