功能性消化不良中医证型与胃肠动力及激素的相关性

目的：研究功能性消化不良（FD）中医辨证分型与胃肠动力及激素之间的关系。方法：选择动力障碍型消化不良患者30例，其中肝郁气滞型16例，脾胃虚弱型14例，并选择正常人20例作为对照组。均进行胃排空、胃窦十二指肠消化间期移行性运动复合波（MMC）、胃电图（EGG）和胃动素的检查，分型统计并进行显著性检验。结果：FD两型的胃排空、MMCⅢ相收缩波幅及协调收缩、空腹胃电主功率均较正常组下降，其中脾胃虚弱组各指标又低于肝郁气滞组，两组间差异有显著性（P＜0．05或P＜0．01）。同时，肝郁气滞组表现为Ⅱ组延长，I相、Ⅲ相不延长；脾胃虚弱组表现为I相延长，Ⅱ相、Ⅲ相缩短。结论：胃排空、MMC、EGG以及胃动素与功能性消化不良中医分型可能有相关性。

Correlation of TCM Syndrome Patterns with Gastrointestinal Motility and Hormones in Functional Dyspepsia

Objective]To investigate the relationship of TCM syndrome patterns with gastrointestinal motility and hormones in functional dyspepsia (FD). Methods] Among 30 cases of dyskinetic FD, 16 with liver depression and qi stagnation were allocated to Group B, 14 with spleen and stomach deficiency to Group C and 20 healthy volunteers served as control group ( Group A). Gastric evacuation, elctrogastrogram (EGG), serum motilin and migrating motor complex (MMC) wave of gastric antrum and duodenum during digestion were examined and analysed statistically. Results]Gastric evacuation, contraction index and amplitude of phase II MMC wave, contraction amplitude and coordinated contraction of phase III MMC wave, and the main power of emptying EGG in empty stomach were decreased in Group B and Group C as compared with those in Group A,and those in Group C were lower than those in Group B, the differences being significant (P<0.05 or P<0.01). Meanwhile,phase II was lengthened and phase I and M not lengthened in Group B, phase I was lengthened, phase II and phase III were shortened in Group C(P < 0.01 as compared with Group A). Conclusion]There is a positive correlation in TCM syndrome patterns of FD with gastric evacuation, MMC wave, EGG and motilin.