| 喉鳞状细胞癌基因表达特点初探 |
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| 引用本文： | 李慧军,姚宪义,王丽妍,李玉春.喉鳞状细胞癌基因表达特点初探[J].哈尔滨医科大学学报,2004,38(3):266-268. |
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| 作者姓名： | 李慧军 姚宪义 王丽妍 李玉春 |
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| 作者单位： | 哈尔滨医科大学第一临床医学院,耳鼻喉科,黑龙江,哈尔滨,150001;哈尔滨医科大学第一临床医学院,耳鼻喉科,黑龙江,哈尔滨,150001;哈尔滨医科大学第一临床医学院,耳鼻喉科,黑龙江,哈尔滨,150001;哈尔滨医科大学第一临床医学院,耳鼻喉科,黑龙江,哈尔滨,150001 |
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| 摘 要： | 目的对与喉鳞状细胞癌关联的基因表达变化的轮廓特征进行描述。方法从相同患者体内检取正常喉上皮和喉鳞状细胞癌应用基因芯片进行分析。结果基因芯片包括4096条，基因表达变化显著差异的有369条，228条上调，141条下调。结论与喉鳞状细胞癌关联的基因涉及原癌基因和抑癌基因、细胞信号和传递蛋白、细胞周期蛋白、细胞骨架、细胞凋亡、免疫等，这些基因反映了喉鳞癌细胞的代谢、生长、信号传递等变化特点。基因芯片技术是基因表达分析有应用前景的技术。
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| 关 键 词： | 基因芯片 喉癌 基因表达 |
| 文章编号： | 1000-1905(2004)03-0266-03 |
| 修稿时间： | 2003年12月12 |
Pilot-study on characterizing the gene expression of laryngeal squamous cell carcinoma |
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| LI Hui jun,YAO Xian yi,WANG Li yan,et al.Pilot-study on characterizing the gene expression of laryngeal squamous cell carcinoma[J].Journal of Harbin Medical University,2004,38(3):266-268. |
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| Authors: | LI Hui jun YAO Xian yi WANG Li yan |
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| Abstract: | Objective To study characterizing the gene expression profile alterations associated with laryngeal squamous cell carcinoma.Methods Normal laryngeal epithelial cells and laryngeal squamous cell carcinoma cells from the same patients and their gene expression profiles were screened using cDNA microarrays.Results A cDNA microarray analysis consisting of 4 096 human genes revealed significant changes in the expression of 369 genes,with 228 genes being up regulated and 141 being down regulated.Conclusion This comprehensive list of genes includes those associated with protooncogene and anti oncogene,ionic channel and traffic protein,signal transduction,cyclin,cytoskeleton,apoptosis,immunity and so on.These genes reflect behaviour changes of metabolism,growth and signal convection of laryngeal squamous cell carcinoma.Microarray technique is a outlook technique of gene expression analysis. |
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| Keywords: | microarray laryngeal carcinoma gene expression |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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