| 人参皂苷Rb1在大鼠肠内菌代谢物吸收入血成分的研究 |
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| 引用本文： | 陈昕,周秋丽,王本祥.人参皂苷Rb1在大鼠肠内菌代谢物吸收入血成分的研究[J].药学学报,1999,34(7):481-483. |
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| 作者姓名： | 陈昕 周秋丽 王本祥 |
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| 作者单位： | 长春中医学院新药研究中心;白求恩医科大学生物工程研究所,长春,130021 |
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| 摘 要： | 目的:研究口服人参皂苷Rb1(G-Rb1)被吸收入血的成分。方法:给大鼠igG-Rb1500mg·kg-1后,于不同时间采集粪、尿及血清样品,用电喷雾质谱(ESI-MS)检测吸收入血成分。结果:在血与尿中发现分子量为1108,946及784amu的代谢产物。经ESI-MS2级质谱分析,上述分子量的化合物分别为G-Rb1,Rd和F2。结论:G-Rb1给大鼠ig后,原形及中间代谢产物Rd及F2被吸收入血。
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| 关 键 词： | 人参皂苷Rb1 Rd F2 肠内菌代谢 电喷雾质谱 |
| 收稿时间： | 1998-09-18 |
STUDY ON THE ABSORBED COMPONENTS IN SERUM AFTER ORAL ADMINISTRATION OF GINSENOSIDE Rb1 IN RATS |
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| Chen Xin,Zhou Qiuli,Wang Benxiang.STUDY ON THE ABSORBED COMPONENTS IN SERUM AFTER ORAL ADMINISTRATION OF GINSENOSIDE Rb1 IN RATS[J].Acta Pharmaceutica Sinica,1999,34(7):481-483. |
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| Authors: | Chen Xin Zhou Qiuli Wang Benxiang |
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| Abstract: | AIM: The experiment was carried out in rats to study the real active component in serum after oral administration of G-Rb1 500 mg·kg-1. METHODS: The metabolites in serum and urine samples were detected using electron spurt ion mass spectroscopy(ESI-MS). RESULTS: Metabolites with molecular weight 1108, 946 and 784 (amu) were shown to be corresponding to Rb1, Rd and F2, respectively. CONCLUSION: Rb1 and its metabolites Rd and F2 were absorbed into serum after oral administration of Rb1. |
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| Keywords: | ginsenoside Rb 1 Rd F 2 intestinal bacteria metabolism electron spurt ion mass spectroscopy (ESI MS) |
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