| 肿瘤血管生成抑制剂的研究进展 |
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| 引用本文： | 华杰,张惠斌,周金培.肿瘤血管生成抑制剂的研究进展[J].中国新药杂志,2011(24). |
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| 作者姓名： | 华杰 张惠斌 周金培 |
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| 作者单位： | 中国药科大学新药研究中心; |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09103-094); 国家自然科学基金(30973638) |
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| 摘 要： | 化学疗法治疗恶性肿瘤常因耐药性使其疗效受到很大限制。抗血管生成治疗的作用靶点为肿瘤内皮细胞,因而很少产生甚至不产生耐药性。文中主要综述目前已开发的几类主要血管生成抑制剂的化学结构、作用机制、抗肿瘤活性及临床应用。
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| 关 键 词： | 抗肿瘤 肿瘤血管生成抑制剂 作用机制 临床应用 |
Advances in the research of tumor angiogenesis inhibitors |
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| HUA Jie,ZHANG Hui-bin,ZHOU Jin-pei.Advances in the research of tumor angiogenesis inhibitors[J].Chinese Journal of New Drugs,2011(24). |
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| Authors: | HUA Jie ZHANG Hui-bin ZHOU Jin-pei |
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| Institution: | HUA Jie,ZHANG Hui-bin,ZHOU Jin-pei(Center for Drug Research,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | In the treatment of tumor,acquired drug resistance is a major problem in chemotherapy.Antiangiogenic therapy directed tumour's endothelial cells should,in principle,induce little or no drug resistance.This review summarized the structures,mechanism of action,anti-tumor activity and clinical application of several major classes of tumor angiogenesis inhibitors. |
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| Keywords: | antitumor antitumor angiogenesis inhibitors mechanism of action clinical application |
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