| 还原型谷胱甘肽合用粉防己碱对帕金森病大鼠脑线粒体酶复合体I及活性氧的影响 |
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| 引用本文： | 曹园园,包仕尧,赵合庆,陆建明,周厚广.还原型谷胱甘肽合用粉防己碱对帕金森病大鼠脑线粒体酶复合体I及活性氧的影响[J].苏州大学学报(自然科学版),2008,28(2):177-180. |
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| 作者姓名： | 曹园园 包仕尧 赵合庆 陆建明 周厚广 |
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| 作者单位： | [1]苏州大学附属第二医院神经内科,江苏苏州215004 [2]常熟市第二人民医院神经内科,江苏常熟215500 |
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| 摘 要： | 目的 观察还原型谷胱甘肽(GSH)合用粉防己碱(Tet)对帕金森病(PD)大鼠氧化应激水平的影响并探讨其作用机制.方法 应用6-羟基多巴立体定向注射制作PD大鼠模型,将成功大鼠模型随机分为模型组、GSH组、GSH Tet组、左旋多巴组,另设正常对照组,给药50d后测定鼠脑黑质线粒体酶复合体I活性及纹状体活性氧(ROS)含量.结果 GSH Tet对PD大鼠黑质线粒体酶复合体I有保护作用,GSH Tet能明显降低PD大鼠纹状体活性氧(ROS)水平.结论 GSH Tet能减轻PD大鼠黑质及纹状体氧化应激损伤,并对线粒体呼吸链有一定保护作用.
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| 关 键 词： | 还原型谷胱甘肽 粉防己碱 帕金森病 线粒体酶复合体I 活性氧 还原型谷胱甘肽 粉防己碱 帕金森病 大鼠脑 线粒体酶复合体 活性氧 影响 Parkinson Disease rats Brain Complex Mitochondrial Tetrandrine Glutathione 线粒体呼吸链 氧化应激损伤 水平 保护 脑黑质 结果 |
The Effect of Glutathione and Tetrandrine on Mitochondrial Complex I and ROS of Brain in rats with Parkinson Disease |
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| CAO Yuan-yuan,BAO Shi-yao,ZHAO He-qing,LU Jian-ming,ZHOU Hou-guang.The Effect of Glutathione and Tetrandrine on Mitochondrial Complex I and ROS of Brain in rats with Parkinson Disease[J].Suzhou University Journal of Medical Science,2008,28(2):177-180. |
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| Authors: | CAO Yuan-yuan BAO Shi-yao ZHAO He-qing LU Jian-ming ZHOU Hou-guang |
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| Institution: | CAO Yuan-yuan1,BAO Shi-yao1,ZHAO He-qing1,LU Jian-ming2,ZHOU Hou-guang2 (1.Dept of Neurology,the Second Hospital Affiliated to Suzhou University,Jiangsu Suzhou 215004,China,2.Dept of Neurology,the Second People Hospital of Changshu,Jiangsu Changshu 215500,China) |
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| Abstract: | Objective To observe the effects of glutathione(GSH) and tetrandrine(Tet) on nigral and striatum antioxidation system and mitochondrial complex I function in Parkinson disease(PD) model rat. Methods The PD rats model were established through stereotoxic microinjection of 6-OHDA.The model rats were randomly divided into 4 groups:model group, GSH group, GSH+Tet group,L-dopa group and normal group. In each group drug treatment was given for 50 days.The activity of mitochondrial complexI in nigra and ROS in str... |
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| Keywords: | glutathione tetrandrine Parkinson disease mitochondrial complex I ROS |
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