中医药干预相关信号通路防治肝癌研究进展

肝癌的发生、发展及微环境中存在着多种信号通路的异常。细胞信号通路的异常持续激活或抑制,调控细胞的增殖、凋亡及迁移,进而影响炎症、血管生成和肿瘤迁移。中医药可通过干预相关信号通路的转导发挥防治肝癌的作用,主要包括刺猬信号通路、IL-6/STAT3信号通路、NF-κB信号通路、PI3K/Akt/mTOR信号通路、MAPK信号通路、TLR信号通路、Wnt信号通路等。现阶段中医药防治肝癌作用确切,但具体机制尚未完全阐明,中医药调控肝癌相关信号通路的研究仍需继续探索。

Research progress on the prevention and treatment of liver cancer intervened by Traditional Chinese Medicine on related signaling pathway

There are many abnormal signaling pathways in the occurrence,development and microenvironment of liver cancer.The abnormal activation or inhibition of cell signaling pathway can regulate cell proliferation,apoptosis and migration,and then affect inflammation,angiogenesis and tumor migration.Experimental studies have shown that Traditional Chinese medicine(TCM)can prevent and treat hepatocellular carcinoma by intervention with the transduction of related signaling pathways,which mainly includes hedgehog signaling pathway,IL-6/STAT3 signaling pathway,NF-κB signaling pathway,PI3K/Akt/mTOR signaling pathway,MAPK signaling pathway,toll-like receptor signaling pathway and Wnt signaling pathway.At present stage,TCM has a definite effect on the prevention and treatment of liver cancer,but the specific mechanism has not been fully elucidated,and the regulation of TCM on liver cancer related signaling pathways still needs further exploration.