| 硫代葡萄糖苷及异硫氰酸酯的抗癌和抗氧化作用进展 |
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| 引用本文： | 林海鸣,郑晓鹤,周军,朱康勤.硫代葡萄糖苷及异硫氰酸酯的抗癌和抗氧化作用进展[J].中国现代应用药学,2015,32(4):513-520. |
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| 作者姓名： | 林海鸣 郑晓鹤 周军 朱康勤 |
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| 作者单位： | 浙江海正药业股份有限公司新药筛选部，浙江 台州 318000,浙江海正药业股份有限公司新药筛选部，浙江 台州 318000,北京军海药业有限责任公司细胞分子药理中心，北京 100141,浙江海正药业股份有限公司新药筛选部，浙江 台州 318000；北京军海药业有限责任公司细胞分子药理中心，北京 100141 |
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| 摘 要： | 目的为硫代葡萄糖苷及异硫氰酸酯的合理利用、功能性保健产品开发和抗癌辅助药物的研制提供依据。方法归纳总结近10年硫代葡萄糖苷和异硫氰酸酯的文献,对其在植物体的分布、理化性质、抗癌和抗氧化机制等方面进行详细阐述。结果硫代葡萄糖苷及其水解产物异硫氰酸酯具有良好的抗癌和抗氧化活性,可以预防和治疗多种癌症,对于由空气污染引发的呼吸系统及肺部疾病也具有良好的疗效;硫代葡萄糖苷及异硫氰酸酯可以清除血管和机体的自由基,保护心脑血管,延缓衰老。结论硫代葡萄糖苷及异硫氰酸酯开发成功能性保健产品和抗癌辅助药具有广阔的市场前景。
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| 关 键 词： | 硫代葡萄糖苷 异硫氰酸酯 抗肿瘤 抗氧化 |
| 收稿时间： | 2014/6/30 0:00:00 |
| 修稿时间： | 2014/10/2 0:00:00 |
Anticancer and Antioxidant Effects of Glucosinolates and Isothiocyanates Progress |
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| LIN Haiming,ZHENG Xiaohe,ZHOU Jun and ZHU Kangqin.Anticancer and Antioxidant Effects of Glucosinolates and Isothiocyanates Progress[J].The Chinese Journal of Modern Applied Pharmacy,2015,32(4):513-520. |
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| Authors: | LIN Haiming ZHENG Xiaohe ZHOU Jun and ZHU Kangqin |
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| Institution: | Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China,Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China,Cellular and Molecular Pharmacology Center, Beijing Junhai Healthcare, Co., Ltd., Beijing 100141, China and Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China; Cellular and Molecular Pharmacology Center, Beijing Junhai Healthcare, Co., Ltd., Beijing 100141, China |
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| Abstract: | OBJECTIVE To provide a full scientific view addressing to reasonable application of Glucosinolates (GLs) and isothiocyanates (ITCs) such as functional health product and anticancer drugs developments. METHODS Summarized the scientific literature about GLs and ITCs in past 10 years. And elaborating current knowledge on three aspects: Distribution in the plant; Physical and chemical properties; Anticancer and antioxidant mechanisms. RESULTS GLs and ITCs have favorable anti-cancer and anti-oxidant activities which can be applied to prevent and treat a variety of cancers. They are also effective for respiratory and lung diseases caused by air pollution. In addition, GLs and ITCs can eliminate the blood vessels free radicals to protect cardiovascular and anti-aging. CONCLUSION GLs and ITCs have broad market prospects to become health care products and assist cancer drugs. |
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| Keywords: | glucosinolates isothiocyanates anti-carcinogenic anti-oxidant |
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