| 橙皮苷与芦丁体外抗高密度脂蛋白氧化修饰的作用 |
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| 引用本文： | 李琴山,娄桂予,钱民章.橙皮苷与芦丁体外抗高密度脂蛋白氧化修饰的作用[J].中西医结合学报,2004,2(2):115-116,119. |
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| 作者姓名： | 李琴山 娄桂予 钱民章 |
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| 作者单位： | 1. 遵义医学院生化教研室,贵州,遵义,563003
2. 第三军医大学生化教研室,重庆,400038 |
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| 摘 要： | 目的:探讨橙皮苷、芦丁体外抗高密度脂蛋白(high density lipoprotein,HDL)氧化的作用.方法:采用一次性密度梯度超速离心方法分离血清HDL,Cu2 诱导HDL氧化,检测反应体系中的丙二醛(malondialdehyde,MDA),观察橙皮苷、芦丁对HDL氧化的抑制作用.结果:橙皮苷、芦丁对Cu2 诱导的HDL氧化有明显的抑制作用,且呈剂量依赖关系.结论:橙皮苷、芦丁体外抗HDL的氧化作用是它们抗动脉粥样硬化的机制之一.
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| 关 键 词： | 橙皮苷 芦丁 高密度脂蛋白 动脉粥样硬化 |
| 文章编号： | 1672-1977(2004)02-0115-02 |
| 修稿时间： | 2003年3月20日 |
Effect of hesperidin and rutin on oxidative modification of high density lipoprotein in vitro |
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| LI Qin-Shan ,LOU Gui-Yu ,QIAN Min-Zhang.Effect of hesperidin and rutin on oxidative modification of high density lipoprotein in vitro[J].Journal of Chinese Integrative Medicine,2004,2(2):115-116,119. |
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| Authors: | LI Qin-Shan LOU Gui-Yu QIAN Min-Zhang |
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| Institution: | Deparment of Biochemistry, Zunyi Medical College, Zunyi Guizhou Province 563003, China. liqinshan333@yahoo.com.cn |
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| Abstract: | Objective:To study the effect of hesperidin a nd rutin on oxidative modification of high density lipoprotein (HDL) in vitro .Methods:HDL was isolated from healthy human plasma by sequen tial ultracentrifugation, and was oxidized by copper ions. The inhibitory effect s of hesperidin and rutin on HDL oxidative modification were valued by the forma tion of malondialdehyde (MDA). Results:Hesperidin and rutin sig nificantly inhibited copper-induced oxidation of HDL in a dose-dependent manne r.Conclusion: Both hesperidin and rutin can prevent HDL from cop per-induced oxidative modification in vitro. This result suggests that they might have antiatherogenic effect. |
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| Keywords: | hesperidin rutin high density lipoproteins atherosclerosis |
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