顶空气相色谱法测定瑞库溴铵中的有机溶剂残留量

目的：建立顶空气相色谱法测定瑞库溴铵中甲醇、乙醚、丙酮、乙腈、二氯甲烷5种有机溶剂残留量的方法。方法：采用DB-624毛细管枉（60mx0．53mmX1岬），柱温为70℃，FID检测器，检测器温度为250℃，进样口温度为150℃，顶空平衡温度为90℃，顶空平衡时间为30min，以水为溶剂。结果：5种溶剂的线性关系良好（r〉0．9996）；平均回收率98．5％～99．8％，检测限为0．03—0．41灿g·ml-1。结论：方法操作简便，重复性好，准确可靠。

Determination of Residual Organic Solvents in Rapacuronium by Headspace Gas Chromatography

Objective： To establish a headspace GC method for the determination of residual organic solvents-methanol, ether, ace- tone, acetonitrile and dichloromethane in rapacuronium. Method： The residual organic solvents were separated on DB-624 capillary col- umn （60 m ×0. 53 mm × 1μm） ,the column temperature was 70 ℃,FID was used as detector with a temperature of 250 ℃ ,the inlet temperature was 150 ℃ ,the equilibrium temperature and time were 90 ℃ and 30 min,the water was used as the solvent. Result： The calibration curves of the five solvents were linear （r 〉 0. 999 6）. the average recoveries were 98.5 % -99. 8%. The detection limits were 0. 03-0. 41 μg.ml-1. Conclusion： The method is simple, repeatable and reliable.