放疗联合唑来膦酸与单纯放疗治疗骨转移瘤疗效比较分析

目的:比较单纯放疗和放疗联合唑来膦酸治疗骨转移癌疼痛的疗效。方法:分析102例骨转移癌疼痛患者治疗效果,A组为放疗+唑来膦酸治疗(47例),B组为单纯放疗(55例),比较两组治疗的总有效率及疼痛缓解期。结果:A组止痛有效率分别为91.5%,明显高于B组的76.4%,两组之间的差异具有统计学意义(P<0.05);随访3个月和7个月后,A组疼痛缓解期大于3个月和7个月的患者百分比分别为67.3%和29.1%,而B组疼痛缓解期大于3个月和7个月的患者百分比分别为87.2%%和40.4%,两组患者疼痛缓解期差异具有统计学意义(P<0.05)。且未发现严重放射及药物毒性。结论:放疗联合唑来膦酸治疗骨转移癌疼痛优于单纯放疗,且可使患者获得更长疼痛缓解期,是一种安全有效的治疗策略。

Comparison between radiotherapy and radiotherapy combined with zoledmnic acid for treatment of metastatic bone tumours

Objective To evaluate the efficacy of radiotherapy and radiotherapy combined with zoledmnic acid to treat metastatic bone tumours.Method Total 102 patients with metastatic bone tumours were divided into two groups.Group A was treated with radiotherapy combined with zoledmnic acid,and group B was treated with radiotherapy.Comparion between the efficiency and pain relief period of the two groups were performed.Results The overall response rate of group A was 91.5%,and that of group B was 76.4%.The difference between the two groups was significant(P<0.05).After 3 months-and 7 months-follow up,the rate of patients with more than 3 months-and 7 months-pain relief period were 67.3% and 29.1%,respectively in group A and those in group B were 87.2% and 40.4%.The difference between the pain relief period of the two groups was significant(P<0.05).Conclusion Radiotherapy combined with zoledmnic acid which is a secure and efficient treatment and provides patients sustained pain relief period is superior to radiotherapy.