| 荞麦花叶总黄酮对大鼠急性压力负荷c-fos蛋白表达的影响 |
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| 引用本文： | 姚文娟,韩淑英,宋会双.荞麦花叶总黄酮对大鼠急性压力负荷c-fos蛋白表达的影响[J].第四军医大学学报,2006,27(7):662-664. |
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| 作者姓名： | 姚文娟 韩淑英 宋会双 |
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| 作者单位： | 华北煤炭医学院药理学教研室,河北,唐山,063000;中国石油天然气集团中心医院神经外科,河北,廊坊,065000 |
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| 基金项目： | 河北省唐山市科技局重点实验室基金 |
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| 摘 要： | 目的:观察荞麦花叶提取的总黄酮(TFBFL)对大鼠急性压力负荷左心室c-fos蛋白表达的影响. 方法:通过腹主动脉狭窄建立心肌肥厚模型,术前给予TFBFL 0.1, 0.2和0.4 g/(kg/d),卡托普利 60 mg/(kg/d). 分别于狭窄后1,3和12 h处死动物取材. 用免疫组化方法检测左室心肌c-fos蛋白的表达. 结果:正常大鼠心肌没有或仅有少量c-fos表达,腹主动脉狭窄后1 h, c-fos表达明显增加,3 h达高峰,较对照组升高约3倍,12 h开始下降. 腹主动脉狭窄后3 h, TFBFL 0.4, 0.2和0.1 g/(kg/d)与心肌肥厚组相比, c-fos表达分别降低21.41%(P<0.01),14.52%(P<0.05)和10.36%. 结论:TFBFL可明显降低c-fos蛋白的表达.
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| 关 键 词： | 心肌肥厚 总黄酮 压力负荷 荞麦 c-fos蛋白 |
| 文章编号： | 1000-2790(2006)07-0662-03 |
| 收稿时间： | 2005-07-14 |
| 修稿时间： | 2005-09-15 |
Effect of total flavones of buckwheat flower and leaf on c-fos protein expression in course of acute pressure overload in rats |
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| YAO Wen-Juan,HAN Shu-Ying,SONG Hui-Shuang.Effect of total flavones of buckwheat flower and leaf on c-fos protein expression in course of acute pressure overload in rats[J].Journal of the Fourth Military Medical University,2006,27(7):662-664. |
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| Authors: | YAO Wen-Juan HAN Shu-Ying SONG Hui-Shuang |
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| Institution: | 1. Department of Pharmacology, North China Coal Medical College, Tangshan 063000, China, 2.Department of Neurosurgery, Central Hospital, China Petroleum Natural Gas Conglomerate, Langfang 065000, China |
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| Abstract: | AIM: To explore the effect of total flavones of buckwheat flower and leaf (TFBFL) on the expression of c-fos protein in the course of acute pressure overload of the left ventricle in rats. METHODS: The rat models of myocardial hypertrophy caused by abdominal aortic banding were given ig TFBFL 0.1, 0.2 and 0.4 g/(kg/d)or captopril 60 mg/(kg/d) before operation. At 1, 3 and 12 h after operation,the expression of c-fos was detected by immunohistochemistry following the sacrification of all rats. RESULTS: The expression of c-fos in the left ventricular had a significant increase after 1 h of abdominal aortic banding and reached a peak at 3 h, decreased at 12 h. Compared with the models of myocardial hypertrophy, TFBFL 0.4, 0.2 and 0.1 g/(kg/d) reduced the expression of c-fos by 21.41% (P< 0.01), 14.52% (P<0.05) and 10.36% after 3 h of abdominal aortic banding. CONCLUSION: TFBFL can decrease the expression of c-fos in the course of acute pressure overload of the left ventricle in rats. |
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| Keywords: | myocardial hypertrophy total flavones pressure overload buckwheat c-fos protein |
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