| 云母颗粒对无水乙醇诱导大鼠胃黏膜损伤的影响及机理探讨 |
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| 引用本文： | 钦丹萍,吕海丽,邵国民,任永葆,韩建新,邱添,黄一鸣.云母颗粒对无水乙醇诱导大鼠胃黏膜损伤的影响及机理探讨[J].浙江中医药大学学报,2008,32(5). |
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| 作者姓名： | 钦丹萍 吕海丽 邵国民 任永葆 韩建新 邱添 黄一鸣 |
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| 作者单位： | 浙江中医药大学第一临床医学院,杭州,310053 |
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| 基金项目： | 浙江省教育厅资助项目 |
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| 摘 要： | 目的]研究云母颗粒对无水乙醇诱导大鼠胃黏膜损伤的保护作用及其机理。方法]将48只健康雄性SD大鼠随机分为云母颗粒高、中、低剂量组，思密达组，模型对照组，空白对照组6组。分别将云母颗粒和思密达预先灌胃于相应各组大鼠，3h后以1ml／100g无水乙醇灌胃致胃黏膜损伤，45min后下腔静脉取适量血，处死取胃，然后分别检测各组的胃黏膜损伤指数、血清和胃黏膜组织中超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）含量，并观察病理学变化，以评价胃黏膜损伤程度及药物的作用。结果]云母各剂量组中SOD、GSH-Px含量均显著高于模型对照组，而MDA含量则明显低于模型对照组（P〈0．05）。结论]云母颗粒对无水乙醇诱导的大鼠胃黏膜损伤具有预防与保护作用，其保护作用是通过增加大鼠血清和胃黏膜组织中SOD、GSH-Px含量并减少MDA的生成来实现的，即云母颗粒具有抗脂质过氧化作用。
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| 关 键 词： | 云母颗粒 无水乙醇 损伤指数 损伤程度 超氧化物歧化酶 丙二醛 谷胱甘肽过氧化物酶 |
Discussion on Mechanism and Effect of Mica Granules on Rats' Stomach Mucosa Injury Induced by Non-water Ethanol |
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| Qian Danping,Lv Haili,Shao Guomin,et al First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou.Discussion on Mechanism and Effect of Mica Granules on Rats' Stomach Mucosa Injury Induced by Non-water Ethanol[J].Journal of Zhejiang University of Traditional Chinese Medicine,2008,32(5). |
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| Authors: | Qian Danping Lv Haili Shao Guomin First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou |
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| Institution: | Qian Danping,Lv Haili,Shao Guomin,et al First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou(310053) |
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| Abstract: | Objective] To study the protection and mechanism of mica granules to rats stomach mucosa injury caused by non-water ethanol.Method] Randomly divide 48 healthy SD rats into high-,middle-and low-dosed groups of mica granules,Simida group,model control group and blank control group as well,i.e.6 groups.After fasting for 24h,separately make stomach perfusion of mica granules and Simida to all rats in advance;after 3h,make stomach perfusion of non-water ethanol 1ml/100g for stomach mucosa injury;45m later,take... |
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| Keywords: | mica granules non-water ethanol injury index injury degree SOD MDA GSH-Px |
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