| 七叶皂苷钠对大鼠视网膜缺血再灌注损伤SOD和MDA的影响 |
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| 引用本文： | 林美英,林水龙,赵晓馥,陈三杰.七叶皂苷钠对大鼠视网膜缺血再灌注损伤SOD和MDA的影响[J].伤残医学杂志,2014(2):20-21. |
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| 作者姓名： | 林美英 林水龙 赵晓馥 陈三杰 |
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| 作者单位： | 晋江市医院眼科,福建晋江362000 |
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| 摘 要： | 目的：探讨七叶皂苷钠对大鼠视网膜缺血再灌注损伤过程中 SOD和MDA表达的影响。方法：采用前房加压法制备大鼠视网膜缺血再灌注损伤模型，将SD大鼠随机分为正常组、缺血再灌注模型组和七叶皂苷钠治疗组，各组于术后3天检测视网膜组织中SOD活性和MDA含量。结果：大鼠视网膜缺血再灌注损伤后，七叶皂苷钠治疗组与缺血再灌注模型组相比，SOD活性明显升高，MDA含量明显降低，差异有统计学意义。结论：七叶皂苷钠可抵抗视网膜缺血再灌注损伤后的氧化损伤，其作用机制可能与提高SOD活性和降低MDA含量有关。
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| 关 键 词： | 七叶皂苷钠 视网膜 缺血再灌注损伤 SOD MDA |
Effect of aescinate on SOD and MDA in rat retina after ischemia-reperfusion injury |
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| Institution: | LIN Mei - ying , LIN Shui - long, ZHAO Xiao - fu , et al. ( Department of Ophthalmology, The Jinjiang City Hospital, Jinjiang, Fujian,362300) |
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| Abstract: | Objective：To investigate the effect of aescinate on the expression of SOD and MDA in rat retina after ischemia -reperfusion injury.Methods：Male adult rats were randomly divided into 3 groups：normal control group , ischemia-reperfusion model group , aesci-nate-treated group.The model of retinal ischemia -reperfusion injury was made by transient elevating of intraocular pressure .The SOD activity and MDA content of retinal tissue were tested on 3 day after operation .Results：The SOD activity of aescinate -treated group was higher than that of ischemia -reperfusion model group , the MDA content of aescinate -treated group was lower than that of ischemia -reperfusion model group .Conclusion：Aescinate against oxidative damage in rat retina after ischemia -reperfusion injury , and its mecha-nism may be related to increasing the activity of SOD and decreased the content of MDA . |
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| Keywords: | Aescinate retina Ischemia-reperfusion injury SOD MDA |
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