糖肾安对糖尿病肾脏高滤过因素影响的实验研究

观察中药糖肾安对链脲霉素糖尿病大鼠肾脏病变的胰高血糖素（ＧＩ）、心钠素（ＡＮＦ）、血清和垂体生长激素（ＧＨ）、血浆血栓素Ｂ２（ＴＸＢ２）和６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）的作用，并与开博通对照，旨在探讨糖肾安治疗糖尿病肾病早期和降低高滤过的机理。结果表明，模型组ＧＩ、ＡＮＦ、血和垂体ＧＨ、血浆ＴＸＢ２和ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值均显著高于正常组（Ｐ＜０．０５～０．００１），６－ｋｅｔｏ－ＰＧＦ１α水平明显降低（Ｐ＜０．０１）；糖肾安组和开博通组垂体ＧＨ含量均较模型组降低（Ｐ＜０．００１）；糖肾安组的ＧＩ、ＡＮＦ、ＴＸＢ２水平及ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值均明显低于模型组（Ｐ＜０．０５～０．０１），并接近于正常组水平（Ｐ＞０．０５），而开博通组这些指标变化均不显著（Ｐ＞０．０５）。提示糖肾安防治糖尿病肾病早期的机理可能是其能够降低ＧＩ、ＡＮＦ和ＧＨ，以改善肾脏高滤过状态；调整ＴＸＡ２与ＰＧＩ２间平衡，抑制血小板活化和防止血管损伤及血栓形成

Experiental study on the effect of Tang Shen An on the factors of diabetic renal hyperfiltration

It was studed that the effect of Tangshen An(TSA) on kindney hyperfiltration factors such as glucagon(G),atrial natriuretic factor(ANF),growth hormone(GH),thromboxaneB 2(TXB 2),6-Kent-prostaglandinF 1α (6-Kent-F 1α ) of diabetic rats induced by streptozocin(STZ),compared with captopril's.The results shown that the level of blood G,ANF,blood and hypophysis GH,blood TXB 2 and TXB 2/6-Kent-TGF 1α ratio was obvious higher and the contents of 6-Kent-PGF 1α was lower in model group than the normal guoup's( P < 0.05 ￣0.001).The contents of G,ANF,TXB 2 and the ratio of TXB 2/6-Kent-PGF 1α decreased in TSA's( P <0.05￣0.01) and unchanged in the captopril's compared with the model's.It was suggesd that TSA could relive the kidney hyperfitration and adjust the balance TXA 2-PGI 2,whih might be mechanism of TSA's treating diabetic renopathy with early stage.