N-末端脑钠肽对脓毒症休克危险分层的价值

目的:分析血浆N-末端脑钠肽(NT-proBNP)水平与脓毒症休克预后的关系。方法:57名研究对象,确诊为脓毒症休克的第2天,抽取静脉血,采用酶联免疫吸附法测定血浆NT-proBNP水平。结果:NT-proBNP≥1 300 pmol/L组死亡风险是NT-proBNP<1 300 pmol/L组的4.1倍(RR4.1,95%CI 1.6～9.7,P<0.01)。APACHEⅡ评分与血NT-proBNP水平正相关(r=0.42,P<0.05)。结论:血浆NT-proBNP水平对判断脓毒症休克的预后有着重要的价值。

N-terminal pro-brain natriuretic peptide for risk stratification in patients with sepsis shock

Objective To determine the relationship of plasma N-terminal pro-brain natriuretic peptide（NT-proBNP） level and the prognosis of sepsis shock.Method Fifty-seven patients with severe sepsis were included.The levels of NT-proBNP were measured on the second day of sepsis by ELISA.Results Septic patients with NT-proBNP levels≥1 300 pmol/L were 4.1 times more likely（relative risk ：4.1;95% CI：1.6~9.7） to die from sepsis than patients with lower NTproBNP values（P0.01）.A highly significant correlation was found between tAPACHE Ⅱ and plasma concentrations of NT-proBNP in septic patients（r=0.42,P0.05）.Conclusion NTproBNP may serve as the useful laboratory marker to predict outcome in patients presenting with severe sepsis.