丹参酮对蛛网膜下腔出血后脑血管痉挛脑灌注及血流动力学的影响

【目的】探讨丹参酮对蛛网膜下腔出血（SAH）后脑血管痉挛（CVS）脑灌注及血流动力学的影响。【方法】将本院200例SAH患者随机分为对照组以及观察组，每组各100例，对照组采用尼莫地平抗CVS，而观察组在对照组基础上采用丹参酮抗CVS，观察比较两组患者脑灌注及血流动力学的变化。【结果】观察组治疗后额叶、颞叶的皮质和白质中脑血流量（CBF）、脑血容量（CBV）显著大于对照组，而平均通过时间（MTT）则少于对照组，且两组相比较差异有显著性（P＜0．05）。治疗后观察组血沉值（ESR）、纤维蛋白原（Fb）、低切变率下全血粘度（nbl）、高切变率下全血粘度（nbh）水平显著低于对照组，且差异有显著性（P＜0．05）。【结论】丹参酮能有效扩张脑血管，改善血液黏稠度及血小板聚集度，增加脑血管血流量，改善脑灌注，降低CVS发生率。

Impact of Tanshinone on Cerebral Perfusion and Hemodynamics of Cerebral Vasospasm after Sub-arachnoid Hemorrhage

Objective To explore the effect of tanshinone on cerebral perfusion and hemodynamics of vaso-spasm（CVS） after subarachnoid hemorrhage（SAH） .Methods]Totally 200 SAH patients in our hospital were randomly divided into control group（ n=100） and observation group（ n=100） .The control group received nimo-dipine for the treatment of CVS ,while the observation group received tanshinone for the treatment of CVS on the basis of the treatment of control group .Cerebral perfusion and hemodynamic changes were observed and compared between two groups .Results]Cerebral blood flow （CBF） and cerebral blood volume（CBV） of the cortex of frontal lobe and temporal lobe in observation group after treatment were markedly higher than those in control group , while the mean transit time（MTT） in observation group was less than that in control group ,and there was signifi-cantdifferencebetweentwogroups（P 〈 0.05）.Erythrocytesedimentationrate（ESR）,fibrinogen（Fb）,blood viscosity under low shear rate（nbl） and blood viscosity under high shear rate（nbh） in observation group after treat-ment were lower than those in control group ,and there was significant difference（ P〈0 .05） .Conclusion] Tanshinone can effectively enhance the dilation of cerebral vessels ,improve blood viscosity and platelet aggregation , increase cerebral blood flow ,ameliorate cerebral perfusion and reduce the incidence of CVS .