| MCP-1在大鼠视网膜缺血再灌注损伤中的实验研究 |
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| 引用本文： | 游志鹏,李国栋,姜德咏,赵宏伟,刘湘平.MCP-1在大鼠视网膜缺血再灌注损伤中的实验研究[J].临床眼科杂志,2003,11(5):473-474. |
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| 作者姓名： | 游志鹏 李国栋 姜德咏 赵宏伟 刘湘平 |
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| 作者单位： | 410011,长沙,中南大学湘雅医学院第二医院眼科 |
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| 摘 要： | 目的 了解视网膜缺血再灌注损伤中不同时期单核细胞趋化蛋白(MPC-1)的表达，探讨其在视网膜缺血再灌注损伤中的作用。方法 对大鼠建立结扎颈总动脉的视网膜缺血再灌注损伤模型，以免疫组织化学法(SABC法)检测视网膜组织中的MCP-1的表达状态。结果 在缺血再灌注损伤1小时，未见MCP-1的表达，在缺血再灌注6小时，MCP-1开始表达，至第24小时表达最强，第48小时开始减弱，但第72小时仍有表达。结论 MCO-1在视网膜缺血再灌注损伤中发挥着重要作用。
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| 关 键 词： | MCP-1 大鼠 视网膜缺血 再灌注损伤 动物实验 免疫组织化学法 |
| 修稿时间： | 2003年6月2日 |
The research of MCP-1 expression in rat's retina which injuried by ischemia-reperfusion |
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| You Zhipeng,Li Guodong,Jiang Deyong,et al..The research of MCP-1 expression in rat''''s retina which injuried by ischemia-reperfusion[J].Journal of Clinical Ophthalmology,2003,11(5):473-474. |
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| Authors: | You Zhipeng Li Guodong Jiang Deyong |
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| Institution: | You Zhipeng,Li Guodong,Jiang Deyong,et al.Department of Ophthalmology,Affiliated 2nd Xiangya Hospital of Central South University,Changsha 410011,China |
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| Abstract: | Objective To study the effect of MCP-1 in rat's retina ischemia-reperfusion injury.Methods To built the rat's retina ischemia-1 in retina.Results There has no MCP-1 expressed in retina after ischemia-reperfusion injury four one hour.MCP-1 began to express in retina after six hours of ischemia-reperfusion injury.And express most after twenty four hours of ischemia-reperfusion injury.Then it began to decrease,but it still express in retina after seventy two hours after ischemia-reperfusion injury.Conclusion MCP-1 take important role in rat's retina ischemia-reperfusion injury. |
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| Keywords: | MCP-1 Ischemia-reperfusion injury Retina |
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