| 宿主p53基因多态性与HPV16感染、宫颈癌发生发展的相关性 |
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| 引用本文： | 严志凌,周红林,张红平,刘熙,张芍,尹春梅,杨宏英.宿主p53基因多态性与HPV16感染、宫颈癌发生发展的相关性[J].昆明医学院学报,2014(5):37-40. |
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| 作者姓名： | 严志凌 周红林 张红平 刘熙 张芍 尹春梅 杨宏英 |
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| 作者单位： | [1]昆明医科大学第三附属医院云南省肿瘤医院,云南昆明650118 [2]昆明医科大学第二附属医院,云南昆明650101 [3]昆明医科大学,云南昆明650500 |
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| 基金项目： | 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（2013FB169） |
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| 摘 要： | 目的 研究宿主p53基因多态性（p53基因第4外显子72位密码子,rs1042522）与HPV16感染、宫颈癌发生发展的相关性.方法 采用TaqMan SNP Genotyping Assays方法进行p53基因多态性（p53基因第4外显子72位密码子）分析.结果 p53基因第4外显子72位密码子的基因型频率和等位基因频率在病例组与HPV16感染组、对照组之间差异有统计学意义（P＜0.01）;但基因型频率和等位基因频率在对照组与HPV16感染组之间无统计学差异,P值分别为0.924和0.870.结论 p53基因第4外显子72位密码子突变与HPV16感染无明显相关性,但是该突变与宫颈癌的发生有相关性.
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| 关 键 词： | p53基因 多态性 HPV16 宫颈癌 |
Correlation of Host p53 Genetic Polymorphism with HPV16 Infection and Development of Cervical Cancer |
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| YAN Zhi-ling,ZHOU Hong-lin,ZHANG Hong-ping,LIU Xi,ZHANG Shao,YIN Chun-mei,YANG Hong-ying.Correlation of Host p53 Genetic Polymorphism with HPV16 Infection and Development of Cervical Cancer[J].Journal of Kunming Medical College,2014(5):37-40. |
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| Authors: | YAN Zhi-ling ZHOU Hong-lin ZHANG Hong-ping LIU Xi ZHANG Shao YIN Chun-mei YANG Hong-ying |
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| Institution: | 1.The 3rd Affiliated Hospital of Kunming Medical University, Yunnan Tumor Hospital, Kunming Yunnan 650118; 2.The 2nd Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101; 3.Kunming Medical University, Kunming Yunnan 650500, China) |
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| Abstract: | Objective To study the correlation of host p53 genetic polymorphism （the 4th Exon of 72 codon in p53 gene） with HPV16 infection and the development of cervical cancer.Methods The TaqMan SNP Genotyping Assays method was used to analyze the p53 gene polymorphism （p53 gene exon 4 of 72 codon）.Results In the gene frequency of p53 gene SNP-rs1042522 and allele frequency,there were statistical differences between the case group and HPV16 infection group,the control group,with the P-value of 0.001 and ＜ 0.001 respectively,while no statistical differences between the control group and HPV16 infection group,with the P-value of 0.924 and 0.870 respectively.Conclusion There is no obvious correlation between the SNP-rs1042522 C/G mutation of the p53 gene and the HPV16 infection,but the mutation has some relevance to the occurrence of cervical cancer. |
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| Keywords: | p53gene Polymorphism HPV16 Cervical cancer |
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