| 蛋白SUMO化修饰与疾病关联性的研究进展 |
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| 引用本文： | 田红伟,夏文戎,扈玉华,徐东刚.蛋白SUMO化修饰与疾病关联性的研究进展[J].军事医学科学院院刊,2013(8):632-634. |
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| 作者姓名： | 田红伟 夏文戎 扈玉华 徐东刚 |
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| 作者单位： | [1]军事医学科学院基础医学研究所,北京100850 [2]河北医科大学第二医院,石家庄050000 |
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| 基金项目： | 国家重大新药创制课题资助（2011ZXJ09101-10B）; 国家自然科学基金资助项目（81071928,81241076） |
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| 摘 要： | 类泛素化修饰蛋白（small ubiquitin-related modifier,SUMO）是一类重要的类泛素蛋白,SUMO化修饰对底物蛋白功能的发挥起着重要的调节作用。SUMO化修饰的异常与人类许多重大疾病密切相关,如肿瘤、神经退行性病变、脑损伤、糖尿病以及家族性扩张型心肌病等。
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| 关 键 词： | SUMO化 修饰 疾病 关联性 |
Relationship between protein sumoylation modification and disease |
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| TIAN Hong-wei;XIA Wen-rong;HU Yu-hua;XU Dong-gang.Relationship between protein sumoylation modification and disease[J].Bulletin of the Academy of Military Medical Sciences,2013(8):632-634. |
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| Authors: | TIAN Hong-wei;XIA Wen-rong;HU Yu-hua;XU Dong-gang |
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| Institution: | TIAN Hong-wei;XIA Wen-rong;HU Yu-hua;XU Dong-gang;Institute of Basic Medical Sciences,Academy of Military Medical Sciences;Department of Neurosurgery,the Second Hospital of Hebei Medical University; |
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| Abstract: | The small ubiquitin-related modifier（SUMO） is an important member of the small ubiquitin like protein（Ubl） family.Sumoylation of proteins is an important regulatory element in mediating protein function.It has been shown that dysregulation of sumoylation is implicated in pathogenesis of human diseases such as cancers,neurodegenerative diseases,brain injuries,diabetes and familial dilated cardiomyopathy. |
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| Keywords: | sumoylation modification disease correlation |
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