| 新型推进剂硝酸羟胺对大鼠血清过氧化物歧化酶活力及丙二醛含量的影响 |
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| 引用本文： | 张蕾,刘志国,邹德威,化楠,李建忠,徐冰心,张坚,常李荣.新型推进剂硝酸羟胺对大鼠血清过氧化物歧化酶活力及丙二醛含量的影响[J].总装备部医学学报,2010(1). |
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| 作者姓名： | 张蕾 刘志国 邹德威 化楠 李建忠 徐冰心 张坚 常李荣 |
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| 作者单位： | 解放军306医院特种伤病科;解放军306医院;解放军306医院医务部; |
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| 基金项目： | 全军“十一五”专项课题(0200Z) |
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| 摘 要： | 目的了解硝酸羟胺对大鼠血清丙二醛(MDA)和过氧化物歧化酶(SOD)含量的影响及其与染毒剂量的关系。方法选择Wister大鼠32只,设置硝酸羟胺50、75、100 mg/kg三个不同剂量组和生理盐水溶剂对照组,每组8只,大鼠腹腔分别注射上述剂量的硝酸羟胺和生理盐水后24 h取血,检测血清中MDA含量及SOD活力。结果大鼠血清中MDA含量随硝酸羟胺染毒剂量的增加呈上升趋势;与溶剂对照组相比,50、75、100 mg/kg剂量组MDA含量均有增加,具有显著性差异(P<0.01,P<0.05)。SOD活力随硝酸羟胺染毒剂量的增加呈下降趋势;与溶剂对照组相比,50 mg/kg剂量组虽有降低但差异不显著(P>0.05);75、100 mg/kg剂量组含量降低,具有显著性差异(P<0.01)。结论腹腔注射硝酸羟胺可引发大鼠血清中脂质过氧化反应增强、抗氧化酶含量降低,氧化损伤可能是硝酸羟胺对机体损害的主要机制。
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| 关 键 词： | 硝酸羟胺 氧化损伤 丙二醛 过氧化物歧化酶 大鼠 |
Effect of hydroxylammonium nitrate on serum superoxidase dismutase and malondialchehychein in rat |
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| ZHANG Lei,LIU Zhi-guo,ZOU De-wei,HUA Nan,LI Jian-zhong,XU Bing-xin,Zhang Jian,CHANG Li-rong.Effect of hydroxylammonium nitrate on serum superoxidase dismutase and malondialchehychein in rat[J].Medical Journal of Central Equipment Headquarters,2010(1). |
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| Authors: | ZHANG Lei LIU Zhi-guo ZOU De-wei HUA Nan LI Jian-zhong XU Bing-xin Zhang Jian CHANG Li-rong |
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| Institution: | ZHANG Lei,LIU Zhi-guo,ZOU De-wei,HUA Nan,LI Jian-zhong,XU Bing-xin,Zhang Jian,CHANG Li-rong.Department of Special Medidine,306 Hospital of PLA,Beijing 100101,China |
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| Abstract: | Objective To observe the effect of hydroxylammonium nitrate(HAN)on serum superoxidase dismutase(SOD) and malondialchehyche(MAD) in rat. Methods Three doses of HAN(50,75,100mg/kg) were administered to rats by intraperitoneal injection and the rats of control group were treated with 0.9% NaCl.Tween-four hours after treatment blood samples were collected for measurements of the activity of SOD and the contents of MDA.Results HAN dose dependently decreased SOD activity and increased MAD production.The differenc... |
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| Keywords: | hydroxylammonium nitrate oxidative damage MDA SOD rat |
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