观音合剂治疗小儿反复呼吸道感染肺脾气虚证的临床研究

目的 观察观音合剂治疗小儿反复呼吸道感染（肺脾气虚证）的临床疗效及其对分泌型免疫球蛋白A（SIgA）的影响,从而初步探讨其作用机制.方法 将80例反复呼吸道感染（肺脾气虚型）患儿随机分为两组,每组各40例,观察组服用观音合剂,对照组服用脾氨肽,疗程1个月,随访6个月.观察各组治疗前后的发病情况及中医证候积分的变化；于用药前、后6个月测定唾液SIgA含量.结果 两组疾病疗效比较,观察组总有效率为85.0％,对照组为65.0％,差异有统计学意义（P＜0.05）；两组中医证候疗效比较,观察组总有效率为90.0％,对照组为62.5％,差异有统计学意义（P＜0.05）；治疗后两组唾液SIgA含量均较治疗前升高（P＜0.01）,且观察组升高更为显著（P＜0.01）.结论 观音合剂能减少反复呼吸道感染（肺脾气虚证）患儿呼吸道感染的次数,改善中医证候,初步推测其作用机制可能与提高患儿SIgA水平有关.

Clinical study on Guanyin Mixture in treating child recurrent respiratory tract infection with lung and spleen Qi deficiency syndrome

Objective To observe the clinical effects of Guanyin Mixture on child recurrent respiratory tract infection （RRTI） with lung and spleen Qi deficiency syndrome and effects on the secretary immunoglobulin A （SIgA） in order to reveal its mechanism of treating this disease.Methods 80 cases of child recurrent respiratory tract infection with lung and spleen Qi deficiency syndrome were randomly divided into 2 groups with 40 cases in each group.The study group was given GuanYin mixture while the control group was given Spleen Aminopeptide.A treatment course was 1 month.After treatments,patients were followed up for 6 months.Before and after treatments the changes of recurrent rate and TCM syndrome score were observed in each group; the content of saliva SIgA was determinated before treatment and 6 months after medication.Results The curative effects of RRTI between 2 groups were compared; the total effective rate was 85％ in study group and 65％ in control group; the difference was statistically significant （P＜0.05）.The curative effects of TCM symdrome between 2 groups were compared;effective rate was 90.0％ in study group and 62.5％ in control group; the difference was statistically significant （P＜0.05）.After treatment saliva SIgA content in 2 groups increased significantly（P＜0.01）,but the changes in treatment group were more significant compared with that in control group（P＜0.01）.Conclusion The Guanyin Mixture can reduce the recurrent rate of RRTI patients with Qi deficiency syndrome of lung and spleen and improve their TCM syndromes.The mechanism may be raising the level of SIgA in patients.