消化道神经内分泌癌中淋巴管密度与淋巴结转移的关系

目的探讨消化道神经内分泌癌组织中淋巴管密度与淋巴结转移的相关性。方法应用免疫组化方法，单克隆抗体D2-40检测经手术切除的55例消化道神经内分泌癌组织的瘤周淋巴管密度（intratumor lymphatic vessel density,iLVD）和瘤内淋巴管密度（intratumor lymphatic vessel density, iLVD），分析2者与患者淋巴结转移之间的关系。结果消化道神经内分泌癌的pLVD明显高于iLVD，淋巴结转移阳性组分别为31．02±1．22与5．29±0．76，淋巴结转移阴性组分别为20．43±1．39与5．64±1．01，pLVD和淋巴结转移相关（P：0．001，r=0．872），与肿瘤的分化程度及淋巴管累及明显相关。iLVD和淋巴结转移无相关性（P=0．293）。结论消化道神经内分泌癌中检测pLVD较iLVD更有价值；pLVD可预测淋巴结转移，有助于判断预后。

Lymphatic vessel density and lymphatic metastasis in gastroduodenal neuroendocrine carcinoma

Objective To investigate the relationship of lymphatic vessel density （LVD）and lymphatic metastasis in gastroduodenal neuroendocrine carcinoma. Methods The intratumor lymphatic vessel deusity （ iL- VD ）and peritumor lymphatic vessel density（ pLVD ）of 55 surgical gastroduodenal neuroendocrine carcinoma tissue samples were detected by immunohistochemistry（ with monoclonal antibody D2-40）. The relationship of lymphatic metastasis and pLVD, iLVD was analyzed. Results The value of pLVD and iLVD was 31.02 ± 1.22 vs 5.29 ± 0. 76 for gastroduodenal neuroendocrine carcinoma with lymph node metastasis, while it was 20. 43 ± 1.39 vs 5.64 ± 1.01 for gastroduodenal neuroendocrine carcinoma without lymph node metastasis, showing pLVD was significantly higher than iLVD in both groups, pLVD of gastroduodenal neuroendocrine carcinoma was closely related to lymph node metastasis （ P = 0. 001, r = 0. 872 ）, the differentiation of carcinoma, and lymphatic involvement while iLVD of gastroduodenal neuroendocrine carcinoma had no relation with lymph node metastasis （P = 0. 293 ）. Conclusion Compared to iLVD detection, pLVD detection is more valuable in gastroduodenal neuroendocrine carcinoma since it can help to predict lymph node metastasis status and the prognosis.