参附注射液联合乌司他丁治疗脓毒症的疗效观察

目的观察参附注射液联合乌司他丁治疗脓毒症的疗效和安全性。方法选取脓毒症病人80例，随机分为对照组和观察组，各40例。对照组予以常规治疗，观察组在常规治疗基础上应用参附注射液联合乌司他丁治疗，比较2组治疗前和治疗后12、24、48 h的急性生理与慢性健康Ⅱ(APACHEⅡ)评分、序贯器官衰竭(SOFA)评分以及血乳酸、降钙素原(PCT)水平，并比较2组ICU住院时间和28 d病死率。结果2组病人治疗前和治疗后12 h的SOFA评分、APACHEⅡ评分差异均无统计学意义(P＞0.05)；治疗后24 h和48 h，观察组SOFA评分和APACHEⅡ评分均明显低于对照组(P＜0.01)。2组病人治疗前血乳酸和PCT差异均无统计学意义(P＞0.05)；治疗后12、24、48 h，观察组血乳酸均明显低于对照组(P＜0.01)；治疗后48 h，观察组PCT明显低于对照组(P＜0.01)。观察组病人ICU住院时间短于对照组(P＜0.05)；观察组病人28 d病死率为17.5%(7/40)，与对照组的27.5%(11/40)差异无统计学意义(P＞0.05)。结论参附注射液联合乌司他丁治疗脓毒症可稳定病情，改善症状，降低病人APACHEⅡ、SOFA评分，改善病人微循环，缩短疗程，具有较好效果。

Effect of Shenfu injection combined with ulinastatin in the treatment of sepsis

ObjectiveTo observe the efficacy and safety of Shenfu injection combined with ulinastatin in the treatment of sepsis.MethodsEighty patients with sepsis were randomly divided into the control group and observation group(40 cases in each group).The control group was treated with routine method, and the observation group was treated with ulinastatin combined with Shenfu injection on the basis of routine method.The changes of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score, sequential organ failure assessment(SOFA) score, levels of blood lactic acid and procalcitonin(PCT) between two groups were compared before and after 12 h, 24 h and 48 h of treatment.The ICU hospitalization days and 28-day mortality rate were compared between two groups.ResultsThe differences of the scores of SOFA and APACHE Ⅱbetween two groups before and after 12 h of treatment were not statistically significant(P＞0.05), and the scores of SOFA and APACHE Ⅱ in observation group after 24 h and 48 h of treatment were significantly lower than those in control group(P＜0.01).The differences of the levels of blood lactic acid and PCT between two groups before treatment were not statistically significant(P＞0.05), and the levels of blood lactic acid in observation group after 12 h, 24 h and 48 h of treatment were significantly lower than that in control group(P＜0.01).The blood lactic acid level in observation group after 48 h of treatment was significantly lower than that in control group(P＜0.01).The hospitalization days in ICU in observation group was obviously lower than that in control group(P＜0.05).The 28-day mortality in the observation group and control group were 17.5%(7/40) and 27.5%(11/40), respectively, and the difference of which was not statistically significant(P＞0.05).ConclusionsThe Shenfu injection combined with ulinastatin in the treatment of sepsis can stabilize the disease, improve the symptoms, reduce the scores of APACHE Ⅱ and SOFA, improve microcirculation of patients, shorten the treatment course, and has good effect.