胎儿纤维连接蛋白与胰岛素样生长因子结合蛋白-1在早产预测中的价值

目的评价胎儿纤维连接蛋白（fFN）和胰岛素样生长因子结合蛋白-1（IGFBP-1）在早产预测中的临床价值。方法选择先兆早产孕妇210例，随机分为三组各70例，应用免疫法定性检测宫颈阴道分泌物中的fFN和IGFBP-1。A组行fFN检测，B纽行IGFBP-1检测，C组行二者联合检测，观察7d、14d内分娩结局，计算三种方法预测早产的灵敏度、特异性、阳性预测值、阴性预测值和诊断符合率。结果A组中19例阳性，51例阴性。B组中21例阳性，49例阴性。C组两者之一阳性或两者均阳性或共33例，两者均阴性37例。三种检测方法在7d和14d内预测的灵敏度、特异度、阳性预测值、阴性预测值和诊断符合率均无显著差异（P〉0.05）。结论fFN和IGFBP-1是预测早产的有效指标，联合应用可最大限度提高诊断符合率。

The values of Fetal fibronectin and insulin-like growth factor binding protein-I in prediction of premature delivery

Objective To evaluate the clinical value of the fetal fibronection（fFN） and insulin-like growth factor binding protein-1（IGFBP-1） in prediction of premature delivery. Methods 210 cases of pregnant women with threatened abortion were randomly divided into three groups, each group have 70 cases. Qualitative detected fFN and IGFBP-I in the cervical vaginal secretions by immunoassays. Group A only detected fFN and group B only detected IGFBP-1, group C detected fFN and IGFBP-1, observation delivery outcome within 1 week, 2 weeks.Then calculate the sensitivity, specificity, positive predictive value, negative predictive value and the diagnosis coincidence rate of each group. Re,fits Group A have 19 positive cases andS1 negative cases. Group B have 21 positive cases and 49 negative cases. Group C have 33 positive cases either or both of fFN and IGFBP-1, and both of fFN and IGFBP-1 were negative 37 cases. Statistical analysis the prognostic sensitivity, specificity, positive predictive value, negative predictive value and the diagnosis coincidence rate within 7 days or 14 days among three groups, and there were no significant difference（P〉0.05）. Conclusion fFN and IGFBP-1 are effective predictors to predict premature delivery, The combined application of fFN and IGFBP-I can improve the diagnosis coincidence rate.