| 鼻咽癌和鼻咽癌前病变中DNA依赖激酶表达的意义 |
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| 引用本文： | 王书芹,周小军,汪芸,王静,禤瑞霞,陈钰炜.鼻咽癌和鼻咽癌前病变中DNA依赖激酶表达的意义[J].齐齐哈尔医学院学报,2008,29(11):1285-1286. |
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| 作者姓名： | 王书芹 周小军 汪芸 王静 禤瑞霞 陈钰炜 |
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| 作者单位： | 广州中医药大学附属医院,中山,528400 |
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| 基金项目： | 广东省中医药管理局科研项目
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中山市科技局课题
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中山市医学课题
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中山市医学科研项目 |
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| 摘 要： | 目的观察鼻咽癌和鼻咽前病变组织中DNA依赖蛋白激酶（DNA-PKcs）的表达变化及其意义。方法在鼻咽癌高发区（广东省中山市）选择鼻咽炎患者30例、鼻咽炎伴鳞状上皮化生、并有不典型增生患者42例及鼻咽癌患者34例,采用免疫组化SP法检测病变组织中DNA-PKcs表达水平。结果鼻咽炎、鼻咽鳞状上皮化生、并有不典型增生患者及鼻咽癌组织中DNA-PKcs表达水平分别为：6.7%、64.3%、58.8%（P〈0.001）,依据病理分类和不典型增生分级的不同,DNA-PKcs呈现不同表达水平。结论DNA-PKcs在鼻咽癌变过程中可能发挥一定的作用。
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| 关 键 词： | 鼻咽炎 鼻咽癌前病变 鼻咽癌 DNA依赖激酶 病理研究 |
The significance of DNA-PKcs expression in precancerous lesion and nasopharyngeal carcinoma |
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| WANG Shu-qin,et al..The significance of DNA-PKcs expression in precancerous lesion and nasopharyngeal carcinoma[J].Journal of Qiqihar Medical College,2008,29(11):1285-1286. |
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| Authors: | WANG Shu-qin |
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| Institution: | WANG Shu-qin, et al. (Affiliated Hospital of Guangzhou Chinese Medicine University, Zhongshan, Guang- dong Province 528400 China) |
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| Abstract: | Objective To investigate the expression of DNA dependent protein kinase(DNA-PKcs) in precancerous lesion and nasopharyngeal carcinoma(NPC).Methods We studied 30 cases of nasopharyngeal inflammation,42 precancerous lesion cases of NPC which involved inflammation,squamous metaplasia and atypical hyperplasia,and 34 cases of NPC,and detected the express of DNA-PKcs with immunohistochemical method(S-P).Results The positive expression rate of DNA-PKcs in nasopharyngeal inflammation,precancerous lesions of NPC,and NPC was 6.7%,64.3%,and 55.9%(P<0.01).Conclusions DNA-PKcs may play an important part in the process of carcinogenesis. |
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| Keywords: | Nasopharyngeal inflammation Precancerous lesions of NPC NPC DNA dependent protein kinase VEGF pathological study |
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