C反应蛋白和心血管疾病研究新进展

CRP作为炎性标志物在心血管疾病的危险性评价中备受关注，其基因多态性可影响血浆CRP水平，部分基因多态性同时和心血管疾病危险性相关。CRP参与动脉粥样硬化形成的全过程，相关机制研究也在逐渐深入。CRP水平升高已成为心血管事件发生的独立危险因素。在ACS的患者，CRP水平升高与粥样斑块不稳定相关，对PCI术后患者心血管事件的发生具有预测价值。即使是CRP水平升高的患者不伴有LDL-c水平升高也能从他汀类药物治疗中获益。

New Progress of C-reactive Protein and Cardiovascular Diseases

As an inflammation-sensitive marker and a risk assessment tool for CVD, CRP gene polymorphisms could influence its blood level, and some were associated with the risk of CVD. CRP was involved in the whole process of atherosclerosis, and relevant mechanisms were studied progressively. CRP has been an independent risk factor for CVD. Levels of CRP were associated with plaque instability in patients with ACS, and future CVD events in ones after PCI. Also, the risk of a first CVD event in individuals with low LDL-C levels but high hs-CRP levels could be decreased with aggressive statin therapy.