| 成人前B急性淋巴母细胞性白血病CD20表达与预后的关系 |
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| 引用本文： | 钟敏,刘晓加,杜庆锋,刘晓力,许娜,刘志,宋兰林,易正山,林榕,夏立平.成人前B急性淋巴母细胞性白血病CD20表达与预后的关系[J].第四军医大学学报,2009,30(4):368-370. |
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| 作者姓名： | 钟敏 刘晓加 杜庆锋 刘晓力 许娜 刘志 宋兰林 易正山 林榕 夏立平 |
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| 作者单位： | 钟敏,夏立平,ZHONG Min,XIA Li-Ping(南方医科大学南方医院,广东广州,510515;海南医学院附属医院,海南海口,570102);刘晓加,杜庆锋,刘晓力,许娜,刘志,宋兰林,易正山,林榕,LIU Xiao-Jia,DU Qing-Feng,LIU Xiao-Li,XU Na,LIU Zhi,SONG Lan-Lin,YI Zheng-Shan,LIN Rong(南方医科大学南方医院,广东广州,510515)
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| 基金项目： | 广州市科技攻关重点引导项目 |
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| 摘 要： | 目的：探讨白细胞分化抗原CD20表达对成人前B急性淋巴细胞性白血病（Pre B-ALL）临床特征及治疗转归的影响。方法：回顾性分析我院2005-01／2008-01成人前B-ALL患者91例临床特征及治疗转归，比较CD20阳性患者及CD20阴性患者第1疗程诱导治疗完全缓解率、持续完全缓解率、髓外浸润率、复发率及2a生存率。结果：91例成人前B-ALL患者中CD20阳性患者43例（47％），CD20阴性患者48例（53％）；CD20阳性与阴性患者经第1疗程诱导治疗后获完全缓解率分别为69.8％（30／43），81.3％（39／48）（P〉0.05），持续完全缓解率分别为11.6％（5／43），41.7％（20／48）（P〈0.05）；髓外浸润率分别为46.5％（20／43），22.9％（11／48）（P〈0.05）；复发率分别为65.1％（28／43），39.6％（19／48）（P〈0.05）；2a总生存率分别为17.3％，47.2％（P〈0.05）。结论：成人Pre B-ALL瘤细胞表达CD20提示预后不良。
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| 关 键 词： | 白血病 淋巴细胞 急性 抗原 CD20 免疫表型分型 成年人 |
Prognostic significance of CD20 expression in adults with precursor B-lineage acute lymphoblastic leukemia |
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| ZHONG Min,LIU Xiao-Jia,DU Qing-Feng,LIU Xiao-Li,XU Na,LIU Zhi,SONG Lan-Lin,YI Zheng-Shan,LIN Rong,XIA Li-Ping,Nanfang Hospital,Southern Medical University,Guangzhou ,China,Affiliated Hospital,Hainan Medical Collage,Haikou.Prognostic significance of CD20 expression in adults with precursor B-lineage acute lymphoblastic leukemia[J].Journal of the Fourth Military Medical University,2009,30(4):368-370. |
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| Authors: | ZHONG Min LIU Xiao-Jia DU Qing-Feng LIU Xiao-Li XU Na LIU Zhi SONG Lan-Lin YI Zheng-Shan LIN Rong XIA Li-Ping Nanfang Hospital Southern Medical University Guangzhou China Affiliated Hospital Hainan Medical Collage Haikou |
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| Institution: | ZHONG Min1,2,LIU Xiao-Jia1,DU Qing-Feng1,LIU Xiao-Li1,XU Na1,LIU Zhi1,SONG Lan-Lin1,YI Zheng-Shan1,LIN Rong1,XIA Li-Ping1,21Nanfang Hospital,Southern Medical University,Guangzhou 510515,China,2Affiliated Hospital,Hainan Medical Collage,Haikou 570102 |
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| Abstract: | AIM: To study the prognostic significance of CD20 expression in 91 adults with precursor B-lineage acute lymphoblastic leukemia(pre-B-ALL).METHODS: The clinical characteristics and outcome of 91 acute lymphoblastic leukemia patients admitted to our hospital between January,2005 and January 2008 were analyzed.The complete remission(CR) rate,continued complete remission rate,extramedullary infiltration rate,relapse rate,and 2-year overall survival rate were compared between CD20 positive and negative patients... |
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| Keywords: | leukemia lymphocytic acute antigens CD20 immunophenotyping adult |
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