| 血清25羟维生素D3水平与2型糖尿病下肢血管病变的关系研究 |
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| 引用本文： | 陈雄,陈恩德,龚小花,谷雪梅,郑景晨,沈飞霞.血清25羟维生素D3水平与2型糖尿病下肢血管病变的关系研究[J].中国全科医学,2011,14(29). |
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| 作者姓名： | 陈雄 陈恩德 龚小花 谷雪梅 郑景晨 沈飞霞 |
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| 作者单位： | 温州医学院附属第一医院内分泌科,浙江省温州市,325000 |
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| 基金项目： | 国家自然青年科学基金项目 |
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| 摘 要： | 目的 探讨血清25羟维生素D325(OH)D3]水平与2型糖尿病患者下肢血管病变(LLPAD)的关系.方法 选取210例2型糖尿病患者(T2DM组),根据下肢血管超声结果将患者分为LLPAD组(94例)和无下肢血管病变 (Non-LLPAD)组(116例),并选取同期来本院体检的50例健康者为对照组.对每位患者进行临床资料收集及常规生化指标检测,采用电化学发光法检测所有受试者血清25(OH)D3水平.结果 LLPAD组患者血清25(OH)D3水平显著降低,与Non-LLPAD组比较差异有统计学意义(P＜0.05).多因素Logistic回归分析发现年龄(OR=1.064,P=0.001)、吸烟(OR=3.639,P=0.001)、舒张压(OR=1.046,P=0.010)、糖化血红蛋白(HbA1c)(OR=1.188,P=0.048)、低密度脂蛋白胆固醇(LDL-C)(OR=1.520,P=0.028)、25(OH)D3(OR=0.096,P=0.001)是糖尿病下肢病变的独立危险因素.结论 低维生素D水平、高龄、吸烟、高HbA1c、高舒张压、高LDL-C与2型糖尿病患者LLPAD的发生密切相关.
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| 关 键 词： | 糖尿病 2型 下肢血管病变 动脉粥样硬化 维生素D 骨化二醇 |
Relationship between Serum 25-Hydroxyvitamin D3 Concentrations and Lower Limb Peripheral Arterial Disease in Type 2 Diabetic Patients |
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| CHEN Xiong,CHEN En-de,GONG Xiao-hua,et al..Relationship between Serum 25-Hydroxyvitamin D3 Concentrations and Lower Limb Peripheral Arterial Disease in Type 2 Diabetic Patients[J].Chinese General Practice,2011,14(29). |
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| Authors: | CHEN Xiong CHEN En-de GONG Xiao-hua |
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| Institution: | CHEN Xiong,CHEN En-de,GONG Xiao-hua,et al.Department of Endocrinology,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China |
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| Abstract: | Objective To explore the relationship between 25-hydroxyvitamin D3 25(OH)D3,VD] and lower limb peripheral arterial disease(LLPAD). Methods A total of 210 type 2 diabetic patients and 50 non-diabetic healthy subjects were enrolled in this study.All the diabetic patients underwent u1trasonography and were divided into 2 groupsLLPAD group(n=94) and non-LLPAD group(n=116)].Clinical data were collected,routine biochemical indices were determined,and serum VD were measured in the diabetic patients and the non-d... |
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| Keywords: | Diabetes mellitus type 2 Peripheral arterial disease Atherosclerosis Vitamin D Calcifediol |
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