GAP基地川芎药材中苯酞类成分的监测

 目的 连续6年动态监测四川灌县徐渡等乡国家GAP示范基地川芎药材中的苯酞类成分,寻找其活性成分藁本内酯和川芎内酯的含量规律。方法 用HPLC测定不同年份产川芎的藁本内酯和川芎内酯的含量。结果 不同年份产川芎药材藁本内酯和川芎内酯的含量之和在1.5％～2.2％之间波动,藁本内酯和川芎内酯的比值基本固定(在2.3～2.6之间波动)。结论 四川灌县徐渡乡产川芎药材具有道地特性,主要苯酞类成分含量与配比基本稳定,为中药道地药材的质量评价和指纹图谱的建立提供了直接的依据。

Investigation of phthalide compounds of Ligusticum chuanxiong in GAP base

OBJECTIVE To investigate the variation of the content of phthalide compounds of Ligusticum chuanxiong Hort. in GAP base of GuanXian of Sichuan province. METHODS The contents of ligustilide and senkyunolide of Ligusticum chuanxiong planted in different years were determined by HPLC. RESULTS The Sum of ligustilide and senkyunolide was about 1.5% - 2.2 % , the ratio of ligustilide and senkyunolide was about 2.3-2.6.CONCLUSION The content and the ratio of ligustilide and senkyunolide were steady,and that provided an important proof for establishing fingerprint pictures of Ligusticum chuanxiong Hort.