| 草苁蓉及氧化苦参碱治疗肝纤维化的实验研究 |
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| 引用本文： | 潘理会,李春辉,孙嘉斌.草苁蓉及氧化苦参碱治疗肝纤维化的实验研究[J].承德医学院学报,2005,22(3):195-198. |
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| 作者姓名： | 潘理会 李春辉 孙嘉斌 |
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| 作者单位： | 承德医学院,河北,承德,067000;延边大学医学院 |
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| 摘 要： | 目的:观察草苁蓉(BR)、氧化苦参碱(OM)治疗大鼠肝纤维化的疗效,为临床治疗提供理论依据.方法:二甲基亚硝胺(DMN)腹腔注射制作肝纤维化的大鼠模型,观察BR、OM治疗后大鼠血清ALT、PCⅢ和CⅣ的变化情况及肝组织的病理学改变.结果:BR、OM可明显提高肝纤维化模型大鼠血清ALT,降低模型大鼠血清PCⅢ和CⅣ(BR、OM组与模型组比较:P＜0.05);另外BR、OM组大鼠胶原纤维面密度和肝纤维化分级与模型组比明显减轻P＜0.05.结论:BR、OM对DMN造模的大鼠肝纤维化有治疗作用.
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| 关 键 词： | 草苁蓉 氧化苦参碱 肝纤维化 大鼠 |
| 文章编号： | 1004-6879（2005）03-0195-04 |
| 收稿时间： | 2005-03-11 |
| 修稿时间： | 2005年3月11日 |
EXPERIMENTAL STUDY ON THERAPEUTIC EFFECTS OF BOSCHNIAKIA ROSSICA AND OXYMATRINE ON HEPATIC FIBROSIS |
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| PAN Li-hui,LI Chun-hui,SUN Jia-bin.EXPERIMENTAL STUDY ON THERAPEUTIC EFFECTS OF BOSCHNIAKIA ROSSICA AND OXYMATRINE ON HEPATIC FIBROSIS[J].Journal of Chengde Medical College,2005,22(3):195-198. |
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| Authors: | PAN Li-hui LI Chun-hui SUN Jia-bin |
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| Abstract: | Objective:To observe the therapeutic effects of boschniakia rossica(BR) and oxymatrine(OM) on hepatic fibrosis in rats, and provide theoretical bases for clinical treatment. Methods: The hepatic fibrosis animal model were made by injecting Dimethylnitrosamine(DMN) into the rats' abdominal cavity. The ALT, PCIII, CIV content in serum and pathological changes of liver were detected after BR, OM were applied. Results:BR, OM could increase the ALT content and decrease the PCIII, CIV content in serum significantly (BR, OM group compared with model group: P<0.05). The collagen fibers density and hepatic fibrosis grade of BR, OM group were significantly alleviated compared with model group (P<0.05). Conclusions:BR and OM has therapeutical effects to hepatic fibrosis induced by DMN. |
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| Keywords: | Hoschniakia rossica Oxymatrine Hepatic fibrosis Rat |
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