| 选择性COX-2抑制剂NS-398的制备 |
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| 引用本文： | 沈义鹏,张爱华.选择性COX-2抑制剂NS-398的制备[J].齐鲁药事,2005,24(7):433-435. |
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| 作者姓名： | 沈义鹏 张爱华 |
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| 作者单位： | 江苏省药物研究所,南京,210009 |
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| 摘 要： | 目的制备选择性COX-2抑制剂NS-398。方法以2-氟硝基苯为起始原料,经4步反应化合成化合物NS-398。结果与结论用该方法可以在温和条件下合成出该药,最终产品纯度大于99%。
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| 关 键 词： | NS-398 COX-2抑制剂 抗肿瘤 还原 化学合成 |
| 文章编号： | 1672-7738(2005)07-0433-03 |
Preparation of selective COX-2 inhibitor NS-398 |
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| Shen Yi-peng,Zhang Ai-hua.Preparation of selective COX-2 inhibitor NS-398[J].qilu pharmaceutical affairs,2005,24(7):433-435. |
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| Authors: | Shen Yi-peng Zhang Ai-hua |
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| Abstract: | Objective To prepare NS-398 which was used as selective COX-2 inhibitor.Methods A facile 4-step synthesis of NS-398 has been performed starting with 2-fluoronitrobenaene.Results and Conclusion The drug was synthesised in high yield under moderate conditions.The purity of the final product was more than 99%. |
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| Keywords: | NS-398 COX-2 inhibitor antitomour reduction chemical synthesis |
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