SHRSP大鼠的脑肾病理学变化

SHRSP大鼠是脑卒中自发性高血压模型动物，是从SHR大鼠中通过选择交配，再经继代近亲繁殖培育而成的。SHRSP大鼠的脑卒中发病率达90％以上，表现为脑出血或脑梗塞，病灶周围脑血管管壁肥厚并有玻璃样变性。血浆高血压蛋白酶原活性升高，相对分子质量变大，血压升高是促使脑卒中发生和发展的前提。经HFC负荷试验，血液中总胆固醇升高5．9—9．7倍，肾病变加重，出现肾小球泡沫细胞。高血压症状持续的时间越长这种细胞出现的频率越高，高血压造成的肾毛细血管损伤加大了脂质的通透性，而高血脂是促进肾病变发展的重要因素。泡沫细胞好发于正在硬化的肾小球，这种选择性分布的特点人与大鼠是一致的，故有可能作为本病的模型使用。

Pathological Changes of the Brain and Kidney of SHRSP Rat

SHRSP rat is the model animal for spontaneously hypertension and stroke, and is cultivated through selective mating and secondary inbred. The incidence of cerebral apoplexy is higher than 90%, and the animals would display cerebral hemorrhage or cerebral infarction, the peri-focus blood vessle walls thickening and in hyaline degeneration, increased renin activity and molecular weight. And raised blood pressure is a prerequisite to cerebral apoplexy occurrence and development. The HFC burden test showed 5.9-9.7 times higher concentration of total cholesterol, severe nephrosis and appearance of renal glomerulus foam cells. The foam cells rose with hypertension continuation. The permeability of lipid rose as the capillary of kidney was damaged following hypertension, and hyperlipemia facilitated the development of nephrosis. The sclerosis of renal glomerulus was accompanied with increased foam cells, whose characteristic of the distribution pattens of human and rat was indentical. It is suggested that SHRSP rat can be used as the model for human disease.