脐带血邻苯二甲酸酯水平及影响因素

目的:探讨澄海区新生儿宫内邻苯二甲酸酯(PAEs)暴露水平及其影响因素.方法:采用气相色谱-质谱联用仪,检测澄海区(暴露组)127例,濠江区(对照组)60例新生儿脐带血血清中5种PAEs水平,并做相关因素问卷调查.结果:暴露组脐带血样本中邻苯二甲酸丁苄酯,邻苯二甲酸二乙基己酯,邻苯二甲酸二正辛酯( DnOP)浓度中位数分别为24.1,648.6,10.1μg/L,显著高于对照组(22.9(P＜0.05)、492.8(P＜ 0.01)、7.2μg/L(P＜ 0.001))；DnOP水平升高与母亲年龄、喝茶习惯负相关.结论:澄海区产妇和新生儿PAEs暴露处于较高水平,采取有效措施降低当地人群特别是母婴PAEs暴露,保护当地人群健康尤为重要.

Phthalate Esters Levels in Umbilical Cord Blood and Related Factors

Objective: To observe phthalate esters(PAEs)levels and related factors from Chenghai area.Methods: One hundred and twenty-seven neonatal umbilical cord blood samples from Chenghai and 60 from Haojiang were collected.PAEs levels were determined by gas chromatography/mass spectrometry.Questionnaire was carried out among subjects.Results: The mean of butylbenzyl phthalate,di(2-ethylhexyl)phthalate,di-n-octyl phthalate(DnOP)levels(24.1,648.6,10.1 μg/L)from Chenghai were significantly higher than Haojiang(22.9,P<0.05;492.8,P<0.01;7.2 μg/L,P<0.001).DnOP level was negatively correlated with mothers’ age and tea consuming.Conclusion: Pregnant women and neonates from Chenghai area are exposured to higher PAEs levels.Adopting effective measures to decrease local people’s PAEs level are needed.