泌尿生殖道支原体感染情况及体外药物敏感性分析

目的 :了解和分析本地区泌尿生殖道解脲支原体 (Ureaplasmaurealyticum ,Uu)和人型支原体 (U .ure alyticum ,Mh)的感染情况及其对 9种抗生素的敏感性。方法 :使用支原体培养及药敏试剂盒对 5 5 7例尿道、宫颈分泌物或前列腺液做支原体培养 ,并对 112例确诊泌尿生殖道支原体阳性标本进行体外药物敏感性试验和分析。结果 :5 5 7例标本中 ,支原体阳性 112例 ,阳性率为 2 0 .10 % ,其中男性阳性率为 14 .0 7% ,女性阳性率为 2 5 .5 1%。 112例支原体培养阳性标本中 ,Uu阳性 74例 (6 6 .1% ) ,Mh阳性 12例 (10 .7% ) ,Uu合并Mh感染 2 6例 (2 3.2 % )。药敏试验显示 ,Uu对强力霉素、美满霉素、克拉霉素有较高的敏感性 ,Mh对强力霉素、美满霉素最敏感 ,Uu合并Mh感染对强力霉素、美满霉素、司帕沙星有较高的敏感性。Uu合并Mh感染对多种药物有较高的耐药性。结论 :Uu和Mh是非淋球菌性尿道炎的主要病原体 ,女性支原体感染率高于男性。泌尿生殖道支原体感染 ,以Uu为主 ,单纯Uu感染与Mh感染以及Uu合并Mh感染对药物耐受性有明显差异。Uu合并Mh感染增强了药物的耐受性 ,扩大了耐药范围。依据当地实验室的药敏结果 ,合理规范选用抗菌素 ,是治疗和控制支原体蔓延的关键。

The infection status of mycoplasma in genitourinary tract and the result of the drug-sensitivity test in vitro

Objective Understand and analyze the i nfection status and sensitivity to 9 kinds of antibiotic of mycoplasma (Ureaplas ma urealyticum, Uu; U.Urealyticum,Mh) in genitourinary tract in this area .Methods A total of 557 patients were enrolled into the study. M ycoplasma culture and drug sensitivity kit were used for the investigation of ur ethra and cervical secretions or prostatic fluid . Mycoplasma positive samples w ith definite diagnosis of 112 patients was performed susceptibility test in vitr o.Results In 557 samples,112 specimens had mycoplasmas,the positive rate is 20.10%, Uu positive rate was 74(66.1%), Mh positive rate was 1 2(10.7%), the positive rate in men was 14.07%,in women was 25.51%.Uu accompanyi ng Mh infection was 26(23.2%)in the 112 mycoplasma positive samples. Susceptibil ity tests showed that Uu had higher sensitivity to Doxicento,Minocycline and Cla rithromycin ;Mh was the most sensitive to the Doxicento and Minocycline;While U u Mh had higher sensitivity to Doxicento,Minocycline and Sparfloxacin .Infection of combining Mh had higher tolerance against many kinds of drugs.Con clusions Uu and Mh were the main pathogens in nongonoccal urethritis; the infection rates of mycoplasma in female are higher than that in male.Mycopla sma infection of genitourinary tract take Uu as the core .It had obvious differe nces in drug-resistance among simple Uu infection,simple Mh infection and Uu wit h Mh infection . Infection of Uu combining with Mh strengthened drug resistance and expanded range of drug resisitance. According to the results of susceptibili ty test in the local laboratory,rational and correct selection of antibiotics sh ould be the key to treat and control mycoplasma spreading.