青龙衣胶囊在荷瘤小鼠体内抗肿瘤活性的研究

目的:研究青龙衣胶囊的抗肿瘤活性及对S 180荷瘤小鼠血清中SOD和MDA的影响。方法:采用人胃腺癌BGC-823,S 180肉瘤和肝癌H 22腹水瘤,分别以环磷酰胺为阳性对照组、生理盐水为阴性对照组,将青龙衣药物以高、中、低3个剂量对实验裸鼠、小鼠组ig给药。结果:青龙衣胶囊明显抑制人胃腺癌BGC-823荷瘤裸鼠瘤体的增长,监测结果显示对给药后期抑瘤作用增强,抑瘤率可达到68.1%(P0.01);能抑制肉瘤S 180荷瘤小鼠瘤体的增长,抑瘤率达到61.2%(P0.01),具有较强的抗氧化能力,显著提高SOD水平(P0.05),降低MDA水平(P0.05);能明显提高肝腹水小鼠的生存质量,延长肝腹水小鼠的带瘤生存时间,生命延长率达到86.6%(P0.01)。结论:青龙衣胶囊具有明显的体内抗肿瘤活性。

Antitumor Activity of Qinglongyi Capsules in Vivo

Objective: Study on antitumor activity of Qilongyi Capsules,and its influence to SOD and MDA in serum of tumor-bearing mice. Method: Used models of human gastric cancer BGC-823,tumors S180, liver cancer H22 ascites tumors.And used the methods of Qilongyi Capsules which were divided into three groups,hig,middle and low. Result: The Qinglongyi Capsules had remarkable affects at suppressing tumor,its inhibition rate on the tumors over 68.1%(P<0.01) to tumor-bearing nude mice and over 61.2%(P<0.01) to tumor-bearing mice,can significantly increase SOD levels(P<0.05) and lower MDA level(P<0.05),and the life span was increased to 86.6%(P<0.01) for mouse with H22 and solid tumors. Conclusions: Through the experiments we can prove that Qilongyi Capsules has remarkable antitumor activity.