maspin、Mn-SOD表达与鼻咽癌组织放疗敏感相关性研究

目的 研究maspin及Mn-SOD在放射治疗鼻咽癌中的表达,探讨其在放射治疗鼻咽癌中的意义.方法 取60例2006年第1次入院放射治疗鼻咽癌,运用原位杂交方法检测放射治疗鼻咽癌中maspin及Mn-SOD mRNA的表达.结果 在放疗敏感及放疗抗拒鼻咽癌中,maspin mRNA中度及强阳性表达率分别为70.00％和42.50％,Mn-SOD mRNA中度及强阳性表达率分别为55.00％和40.00％,差异有统计学意义.在放疗抗拒鼻咽癌中,maspin及Mn-SOD mRNA中度及强阳性表达率均与T分期呈正相关,T3和T4期中表达率分别为63.16％和63.16％,T1和T2期中表达率分别为23.81％和19.05％.在有、无远处转移中,maspin mRNA中度及强阳性的表达率分别为72.73％和31.03％,Mn-SOD mRNA中度及强阳性表达率分别为81.82％和24.14％,差异有统计学意义.结论 maspin、Mn-SOD参与了放射抗拒鼻咽癌的发展.

Expressions of Maspin and Mn-SOD gene in Radiotherapy Nasopharyngeal Carcinoma

Objective To study the expressions of maspin and Mn-SOD in the radiotherapy of nasopharyngeal carcinoma,as well as their significances in radiotherapy nasopharyngeal carcinoma.Methods Radiotherapy nasopharyngeal carcinoma when their first admission was in 2006 was selected with 60 cases,in situ hybridization detections of maspin and Mn-SOD mRNA expressions were carried out.Results In radiosensitivity and radioresistance of nasopharyngeal carcinoma,the moderately and strongly positive maspin mRNA expression rates were 70.00% and 42.50%,and the moderately and strongly positive Mn-SOD mRNA expression rates were 55.00% and 40.00%.There was statistical significance difference.In the radioresistance of nasopharyngeal carcinoma,Maspin and Mn-SOD mRNA moderately and strongly positive expressions were positively correlated with T stage.In the degree of T3 and T4,Maspin had moderately and strongly positive expression rate of 63.16%,Mn-SOD had moderately and strongly positive expression rate of 63.16%.In the degree of T1 and T2,Maspin had moderately and strongly positive expression rate of 23.81%,Mn-SOD had moderately and strongly positive expression rate of 19.05%.In distant metastasis and no distant metastasis,the expression rates of Maspin were 72.73% and 31.03%,the expression rates of Mn-SOD were 81.82% and 24.14%,and the difference had statistical significance.Conclusion Maspin and Mn-SOD have participated in the development of radioresistant nasopharyngeal carcinoma.