脑心舒软胶囊对大鼠的长期毒性实验研究

目的 观察脑心舒软胶囊连续给药后对大鼠的毒性反应.方法 SD大鼠分为脑心舒软胶囊高、中、低剂量组（分别为生药36、18、9g/kg）和空白对照组,每组20只.连续灌胃给药13周,观察大鼠一般状况、体重和摄食量变化.于末次给药后和停药两周后分别取部分大鼠,检测血液学指标、血液生化学指标、脏器系数及病理组织学改变.结果 与空白对照组比较,各给药组对大鼠的生长发育、血液学指标、血液生化学指标、脏器系数及病理组织学均无显著影响（P＞0.05）,恢复期未见药物引起的迟发性毒性反应.结论 脑心舒软胶囊相当于临床人用药剂量的15 ～60倍对大鼠长期给药,未见明显毒性不良反应.

Long-Term Toxicity of Naoxinshu Capsule in Rats

Objective To investigate the long - term toxicity reaction in rats given Naoxinshu capsule （NC） continuously. Methods SD rats were divided into 4 groups at random （n = 20） , namely normal control, NC high, medium and low dose groups （36, 18 and 9 g/kg, respectively）. NC was oral administered for 13 weeks. The body weight and food intake was observed and calculated during the administration. The hematology and blood biochemistry analysis were carried out, and organ histopathological changes were also observed under the mi- croscope at the end of the administration and 2 weeks after the administration, respectively. Results The outer appearance and behavior, body weights, organ coefficients, hematology analysis, biochemistry analysis and histopathological observation in rats of NC groups showed no significant difference compared to the normal control group. No delayed toxicity reaction was observed 2 weeks after the administration. Conclusion NC （equivalent to 15 -60 times of the clinical dose） showed no obvious toxicity in rats for long - term administration.