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| 含阿魏酸的川芎效应组分缓释微丸的 制备及性质考察 | |
| 引用本文： | 洪燕龙,林晓,冯怡,徐德生,陈丽华.含阿魏酸的川芎效应组分缓释微丸的 制备及性质考察[J].中国中药杂志,2011,36(4):439-442. |
| 作者姓名： | 洪燕龙 林晓 冯怡 徐德生 陈丽华 |
| 作者单位： | 1. 上海中医药大学,中药现代制剂技术教育部工程研究中心,上海,201203 2. 上海中医药大学,中药现代制剂技术教育部工程研究中心,上海,201203;上海中医药大学中药学院,上海,201203 3. 江西中医学院,江西南昌,330004 |
| 基金项目： | 上海市教育委员会科研创新项目(09YZ117);上海市教育委员会重点学科项目(J50302) |
| 摘 要： | 目的:以流化床包衣法制备含阿魏酸的川芎效应组分(ACC)的缓释微丸.方法:采用挤出-滚圆法制备ACC速释微丸,以阿魏酸的体外释放度为考察指标,优化ACC缓释微丸的包衣液处方,并评价该缓释微丸的粉体学性质和缓释效果.结果:ACC缓释微丸圆整度好,在12 h内体外缓慢释药,尤特奇(Eudragit RS 100)的用量是影响微丸释药的主要因素.结论:制备的ACC缓释微丸在体外达到较好的缓释效果. |
| 关 键 词： | 川芎 缓释微丸 流化床 尤特奇 |
| 收稿时间： | 2010/8/23 0:00:00 |
Preparation and properties of sustained-release pellets of active components from Ligusticun chuanxiong |
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| HONG Yanlong,LING Xiao,FENG Yi,XU Desheng and CHEN Lihua.Preparation and properties of sustained-release pellets of active components from Ligusticun chuanxiong[J].China Journal of Chinese Materia Medica,2011,36(4):439-442. | |
| Authors: | HONG Yanlong LING Xiao FENG Yi XU Desheng and CHEN Lihua |
| Institution: | Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine,Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine,Shanghai 201203, China;School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine,Shanghai 201203, China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine,Shanghai 201203, China;School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China |
| Abstract: | Objective : To prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed. Method : The fast-release pellets were prepared by the extrusion-spheronization process. The coating formulation was optimized with the release of ferulic acid as criteria. The micromeritic properties and drug dissolution behaviors of the prepared pellets were evaluated. Result : The pellets presented perfect sphericity. The obviously sustained-release effects were shown in 12 h. The coating weight gain was the major factor impacting drug release. Conclusion : The coating pellets show the obviously sustained-release effects. |
| Keywords: | Ligusticun chuanxiong sustained-release pellet fluid-bed eudragit |
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