| 用于乙肝疫苗效力检定的NIH-q小鼠种群的建立 |
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| 引用本文： | 邢瑞昌,宋珍珠,刘双环,李秀华,胡宗汉,李德富.用于乙肝疫苗效力检定的NIH-q小鼠种群的建立[J].中国比较医学杂志,1991(1). |
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| 作者姓名： | 邢瑞昌 宋珍珠 刘双环 李秀华 胡宗汉 李德富 |
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| 作者单位： | 中国药品生物制品检定所 北京
(邢瑞昌，宋珍珠，刘双环，李秀华，胡宗汉)，中国药品生物制品检定所 北京(李德富) |
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| 摘 要： | 用7个近交系及两个NIH封闭群小鼠分别测定同一样品乙肝疫苗的免疫原性,由不同品系小鼠求出的ED_(50)值之间有显著差异,且该反应差异性与小鼠的H-2单倍型密切相关.NIH小鼠H-2基因的杂合性影响乙肝疫苗效力检定结果的准确性。通过对NIH小鼠的遗传选择,建立了H-2单倍型为q,对HBsAg免疫应答性较为一致的NIH-q种群,同时保持了原封闭群动物繁殖力强、生长速度快等优点.
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| 关 键 词： | 乙肝疫苗 免疫原性 小鼠 |
Selection of a Mouse Colony for the Potency Testing of HB Vaccine |
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| Xing Reizhang.Selection of a Mouse Colony for the Potency Testing of HB Vaccine[J].Chinese Journal of Comparative Medicine,1991(1). |
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| Authors: | Xing Reizhang |
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| Abstract: | By using 7 inbred strains and 2 outbred NIH colonies of mice, the potency testing of Hepatitis B vaccine was performed. Significant differences were found between potency estimates derived from assays using different strains of mice. And it was likely that the variation of immune response to HB vaccine in mice was correlative with the H-2 haplotypes. Based on our experiments, a breeding selection has been made from the NIH colony for eliminating both non-q haplotype-bearing individuals and other poor res-ponders to HB vaccine.This new established colony is hopeful to become a standard stock for potency testing of HB vaccine in China. |
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| Keywords: | HB vaccine Immunogeuicity mice |
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