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| 组蛋白去乙酰酶抑制剂下调脓毒症小鼠肝内粘附分子表达 | |
| 引用本文： | 王彬,张力,万敬员,姜蓉,闵苏.组蛋白去乙酰酶抑制剂下调脓毒症小鼠肝内粘附分子表达[J].重庆医科大学学报,2011,36(1):8-11. |
| 作者姓名： | 王彬 张力 万敬员 姜蓉 闵苏 |
| 作者单位： | 1. 重庆医科大学附属第一医院麻醉科 2. 重庆医科大学基础医学院病理生理学教研室 3. 重庆医科大学药学院药理学教研室,重庆,400016 |
| 基金项目： | 重庆市教委科学技术研究项目 |
| 摘 要： | 目的:研究组蛋白去乙酰化酶抑制剂对脓毒症小鼠肝内粘附分子表达及炎症细胞浸润的影响.方法:小鼠经腹腔注射组蛋白去乙酰化酶抑制剂(TrichostatinA或丁酸钠)后,行盲肠结扎穿孔术以诱导小鼠脓毒症.18 h后处死小鼠并收集血清和肝组织,检测血清转氨酶活性及肝组织匀浆髓过氧化物酶活性;常规石蜡切片HE染色观察组织病理学... |
| 关 键 词： | 组蛋白去乙酰化酶 脓毒症 粘附分子 炎症 盲肠结扎穿孔术 |
Histone deacetylase inhibitors down-regulate hepatic expression of adhesion molecules in septic mice |
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| WANG Bin,et al.Histone deacetylase inhibitors down-regulate hepatic expression of adhesion molecules in septic mice[J].Journal of Chongqing Medical University,2011,36(1):8-11. | |
| Authors: | WANG Bin |
| Institution: | WANG Bin,et al(Department of Anesthesiology,the First Affiliated Hospital,Chongqing Medical University) |
| Abstract: | Objective:To investigate the effects of histone deacetylase(HDAC) inhibitors on the expression of adhesion molecules in liver tissue and the infiltration of leukocytes in liver tissue during the progression of sepsis.Methods:C57BL/6 mice were pre-treated with two structure unrelated HDAC inhibitors,Trichostatin A or sodium butyrate,and then sepsis was induced by cecal ligation and puncture(CLP).At 18 h after CLP,hepatic expression of adhesion molecules,including intercellular adhesion molecule-1(ICAM-1) and... |
| Keywords: | histone deacetylase sepsis adhesion molecule inflammation cecum ligation and puncture |
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