| 超氧化物歧化酶和丙二醛在几种心血管疾病中的变化 |
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| 引用本文： | 郑玉云,张朝,郭晓华,张杰梅,孙淑艳.超氧化物歧化酶和丙二醛在几种心血管疾病中的变化[J].包头医学院学报,2002,18(3):175-176. |
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| 作者姓名： | 郑玉云 张朝 郭晓华 张杰梅 孙淑艳 |
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| 作者单位： | 1. 包头医学院一附院ICU,内蒙古,包头,014010
2. 包头医学院一附院骨科,内蒙古,包头,014010 |
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| 摘 要： | 目的：观察超氧化物歧化酶（SOD）和丙二醛（MDA）在心血管疾病中的变化，方法：对156例心血管疾病患者（肺心病41例，冠心病77例和高血压38例）分别测定血清SOD和MDA的含量。结果：与正常对照组比较，心血管病组血清SOD下降了38．78％（P＜0．01），MDA升高了140．58％（P＜0．01），SOD／MDA值下降了73．30％（P＜0．01），结论：在心血管疾病患者中自由基代谢紊乱，提示自由基触发的脂质过氧化反应可能参与了这些疾病的发生和发展。
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| 关 键 词： | 超氧化物歧化酶 丙二醛 心血管疾病 脂质过氧化 |
| 文章编号： | 1006-740X(2002)03-0175-02 |
| 修稿时间： | 2002年6月19日 |
Changes of SOD,MDA in Several Cardiovascular Diseases |
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| Zheng Yuyun,Zhang Zhao,Guo Xiaohua,et al.Changes of SOD,MDA in Several Cardiovascular Diseases[J].Journal of Baotou Medical College,2002,18(3):175-176. |
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| Authors: | Zheng Yuyun Zhang Zhao Guo Xiaohua et al |
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| Abstract: | Objective: To observe the changes of superoxide dismutase (SOD) and malonyldialdehyde(MAD) in several cardiovascular diseases. Methods:The levels of SOD and MDA of 156 cases with cardiovascular diseases were measured, (41 of them were cor pulmonale ; 77 were coronary heart disease; 38 were hypertension). Results: Compared with the control group, the level of SOD dropped by 38.78% in cardiovascular diseases group (P<0.01), that of MDA was lowered by 140.58% (P<0.01), SOD/MDA was decreased by 73.30% (P<0.01) . Conclusion: The free radial metabolism was disordered in cor pulmonale, coronary heart disease and hypertension. It is saggestd that the free radical-induced lipid peroxidation may contribate to the incidence and the development of these diseases |
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| Keywords: | Cor pulmonale Coronary heart disease Hypertension SOD MDA |
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