| 海洋来源真菌杂色曲霉的化学成分及其抗肿瘤活性研究 |
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| 引用本文： | 倪敏,张丽华,林燕喃,邓昌良.海洋来源真菌杂色曲霉的化学成分及其抗肿瘤活性研究[J].中国海洋药物,2018,37(2):76-80. |
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| 作者姓名： | 倪敏 张丽华 林燕喃 邓昌良 |
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| 作者单位： | 福建卫生职业技术学院,福建卫生职业技术学院药学系,福建卫生职业技术学院药学系,福建卫生职业技术学院药学系 |
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| 基金项目： | 福建省教育厅中青年项目(JAT171039)；福建卫生职业技术学院校级课题(2017–1–2)资助 |
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| 摘 要： | 目的研究一株海洋来源真菌Aspergullus versicolor NM-021杂色曲霉的化学成分及其抗肿瘤活性。方法利用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC等色谱技术对其化学成分进行分离、纯化；通过NMR、MS方法，结合与文献报道的数据比对，对化合物的结构进行鉴定。运用细胞毒活性筛选模型对其抗肿瘤活性进行初步评价。结果从该菌株中分离得到了2个蒽醌类化合物2H-6-O-Methylaverufin（1）和6-O-Methylaverufin（2）。生物活性测试结果表明，化合物1对人结肠癌和食管癌具有一定的抑制活性。结论从该菌株中分离得到1个新的具有细胞增殖抑制活性的蒽醌类化合物（1）。
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| 关 键 词： | 蒽醌 杂色曲霉 次级代谢物 细胞毒活性 |
| 收稿时间： | 2017/10/15 0:00:00 |
| 修稿时间： | 2017/12/15 0:00:00 |
Study on chemical constituent and antitumor activity of a marine-derived fungus Aspergullus versicolor |
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| NI Min,ZHANG Li-hu,LIN Yan-nan and DENG Chang-liang.Study on chemical constituent and antitumor activity of a marine-derived fungus Aspergullus versicolor[J].Chinese Journal of Marine Drugs,2018,37(2):76-80. |
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| Authors: | NI Min ZHANG Li-hu LIN Yan-nan and DENG Chang-liang |
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| Abstract: | Objiective To study the chemical constituent and antitumor activity of a marine-derived fungus Aspergullus versicolor NM-021. Methods The compounds were purified by silica gel and Sephadex LH-20 column chromatography, followed by semi-preparative HPLC. Their structures were identified by NMR and MS analysis as well as comparison with literatures. Results Two anthraquinones, 2H-6-O-Methylaverufin (1) and 6-O-Methylaverufin (2) were isolated from this marine-derived fungus Aspergullus versicolor. Compound 1 showed moderate cytotoxic effects against the cell line of colon and esophageal cancer. Conclusion A novel anthraquinone (1) with cytotoxic activity was isolated from this fungus. |
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| Keywords: | anthraquinone Aspergullus versicolor secondary metabolite cytotoxitic activity |
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