发酵乳增效治疗幽门螺杆菌的Meta分析

目的：系统评价发酵乳联合常规治疗方案清除幽门螺杆菌(Helicobacter pylori，H. pylori)感染的临床疗效。 方法：通过检索Pubmed，Embase，中国知网，中国生物医学文献数据库，万方知网和维普等数据库，收集各数据库建库至2015年2月间与发酵乳辅助治疗H. pylori感染相关研究的随机试验或半随机对照试验，分析根除率与不良反应发生率的合并RR值，并进行亚组、敏感性分析和发表偏倚检测。结果：共纳入9项(1 644例)研究，发酵乳联合常规根除疗法与单独常规根除疗法H. pylori根除率分别为79.5%和67.0%，其合并RR为1.186(95%CI: 1.118~1.257)。总不良反应发生率的合并RR为0.706(95%CI: 0.373~1.340)。结论：益生菌可提高常规疗法对H. pylori的根除率，但不能有效降低不良反应的发生风险。

Fermented milk can act as adjunctive therapy for Helicobacter pylori infection: A Meta-analysis

Objective: To systematically evaluate the clinical effect of cultured milk products as adjunctive therapy in the anti- Helicobacter pylori (H. pylori) treatment. Methods: The randomized controlled trials (RCT) and Quasi-randomized controlled clinical trials (Quasi-RCT), which were used to evaluate the efficacy and safety of eradicating H. pylori by fermented milk-based routine treatment, were searched and collected in Pubmed, Embase, CNKI (China National Knowledge Infrastructure), CBM (Chinese BioMedical Literature Database), Wangfang Database, VIP (VIP Citation Database) from establishment of these database to February 2015. The combined relative risk (RR) of H. pylori eradication rate and the rate of side effects were analyzed. Sub-group and sensitivity analysis was performed, and the publication bias was also tested. Results: A total of 9 studies including 1 644 cases were identified. The H. pylori eradication rate was 79.5% in fermented milk products combined with routine therapy, and 67.0% in routine therapy. The combined RR of H. pylori eradication rate was 1.186 (95% CI 1.118–1.257), and the combined RR of total side effects was 0.706 (95% CI 0.373–1.340). Conclusion: Cultured milk products as adjunctive therapy is effective in improving the eradication rate during eradication therapy for H. pylori. However, it could not effectively decrease the risk of side effects.