| 改良磷酸钙骨水泥修复兔桡骨骨缺损的实验研究 |
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| 引用本文： | 李亮,王新家,孔抗美,姚关锋,齐伟力,林家钟.改良磷酸钙骨水泥修复兔桡骨骨缺损的实验研究[J].汕头大学医学院学报,2011,24(2):91-94,62. |
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| 作者姓名： | 李亮 王新家 孔抗美 姚关锋 齐伟力 林家钟 |
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| 作者单位： | 1. 汕头大学医学院第二附属医院关节脊柱外科,广东汕头,515041
2. 福建省人民医院普外科,福建福州,350004 |
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| 基金项目： | 广东省科技计划资助项目(2008B080701033,2009B080701040); 广东省自然科学基金博士启动基金资助项目(8451503102001818) |
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| 摘 要： | 目的：比较改良磷酸钙骨水泥（CPC）与普通CPC修复兔桡骨骨缺损的效果,并探讨其作为修复骨缺损植骨替代材料的可行性。方法：新西兰大白兔36只随机分为改良CPC组,普通CPC组和对照组。3组均于双侧桡骨中下段制作骨缺损,改良CPC组植入改良CPC棒,普通CPC组植入普通CPC棒,对照组不植入任何物质。于术前、术后2、4、8、12周检测3组血清中Ca2＋、P3-、碱性磷酸酶（ALP）浓度;分别于术后2、4、8、12周对3组行X光摄片;术后8、12周分批处死之,取桡骨标本做扫描电镜。结果：术后12周改良CPC组骨缺损修复良好,骨水泥完全降解;普通CPC组新骨形成相对较少,骨水泥残留;改良与普通CPC组术后血清中Ca2＋及ALP浓度比有统计学意义（P〈0.05）;扫描电镜观察显示改良CPC组骨修复完全,可见材料与宿主骨原交界面。结论：改良CPC较普通CPC有更好的骨缺损修复能力及生物降解性。
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| 关 键 词： | 磷酸钙骨水泥 骨缺损 兔 |
Experimental Study of Repairing Rabbit Radius Bone Defects with Modified Calcium Phosphate Bone Cement |
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| LI Liang
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WANG Xin-jia
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KONG Kang-mei
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YAO Guan-feng
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QI Wei-li
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LIN Jia-zhong.Experimental Study of Repairing Rabbit Radius Bone Defects with Modified Calcium Phosphate Bone Cement[J].Journal of Shantou University Medical College,2011,24(2):91-94,62. |
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| Authors: | LI Liang WANG Xin-jia KONG Kang-mei YAO Guan-feng QI Wei-li LIN Jia-zhong |
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| Institution: | LI Liang,WANG Xin-jia,KONG Kang-mei,YAO Guan-feng,QI Wei-li,LIN Jia-zhong(1 Depertment of Orthopedics,The Second Affiliated Hospital,Shantou University Medical College,Shantou 515041,China,2 General Surgery,People's Hopital of Fujian Provice,Fuzhou 350004,China) |
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| Abstract: | Objective:To evaluate the effect of modified calcium phosphate bone cement(CPC)and coercial CPC in repairing rabbit radius bone defects,and to discuss the feasibility of modified CPC as bone substitution materials.Me-thods:The animal models of bilateral radius bone defects were establisbed in thirty-six New Zealand white rabbits,which were randomly classificated for modified CPC,coercial CPC and control groups.The modified CPC rods were implanted into bone defects areas in the modified CPC group,the coercia... |
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| Keywords: | calcium phosphate bone cement bone defect rabbit |
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